TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Hemorrhage, Surgical, Tonsillar Bleeding

In brief

After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the sore spot. If this mist works well, it could help kids get better by making sure they don't have to go back for more surgery or need blood from someone else. Not having another surgery is good because it means kids won't have to sleep under medicine again, which can sometimes be risky for their brains and breathing, and they won't feel as scared or hurt.

Key facts

Study ID

NCT06580509

Run by

The University of Texas Health Science Center at San Antonio

People needed

12

Starts

2026-02-18

Expected to finish

2028-09-30

Last updated by the study team

2026-04-24

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Received a tonsillectomy
• Presents to the ED with secondary* post-tonsillectomy hemorrhage
• Children between age of 2 to 17 years of age (i.e., before their 18th birthday) *Secondary post-tonsillectomy hemorrhage is defined as greater than 24 hours from their primary tonsillectomy operation (arrival in recovery/PACU).

You may not qualify if…

• Known and documented bleeding or clotting disorder.
• Known pregnancy.
• Patients with known hypersensitivity or allergic response to tranexamic acid.
• Parents or guardians who cannot communicate in English or Spanish.
• Intubation prior to enrollment.
• Previously enrolled patients.

Where it is running

• University Hospital — San Antonio, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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