The EEG Study Under Sevoflurane Anesthesia in Children
Recruiting now
Conditions studied: Electroencephalography, Sevoflurane, Child Neglect
In brief
Sevoflurane is one of the most commonly used volatile anesthetics in children because of its rapid induction, recovery and recovery properties. Clinical studies using noninvasive brain monitoring have shown that general anesthetics and hypnotics generate electroencephalogram (EEG) oscillations in specific spatial tissues that are fundamentally related to the structure and function of neural circuits. Slow-wave-delta (0.1-4 Hz) oscillations were present in children of all ages, and the advantage of frontal α-wave oscillations appeared at approximately 6 months, began to be consistent at 10 months, and persisted at older ages. Another study, which analyzed EEG under sevoflurane general anesthesia in children aged 0-6 months, found that Theta and alpha wave power decreased with a decrease in sevoflurane concentrations in infants between 4 and 6 months of recovery. However, these studies lack detailed characterization of the neural circuit activity associated with anesthesia, especially at specific developmental ages that are highly correlated with brain plasticity. The aim of this study was to explore electroencephalogram (EEG) of children of different ages under sevoflurane general anesthesia (including anesthesia induction, maintenance and recovery) . By analyzing these EEG data in detail, we hope to be able to better understand the EEG characteristics of children of different ages under sevoflurane anesthesia, and thus develop a neurophysiology pediatric anesthesia status monitoring strategy.
Key facts
- Study ID
- NCT06580028
- Run by
- Second Affiliated Hospital of Wenzhou Medical University
- People needed
- 280
- Starts
- 2024-09-04
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2025-02-07
Who can join
Age: 0 and older, up to 6. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- aged 1 days#6 years#;
- with American Society of Anesthesiologists (ASA) physical status I or II#;
- children requiring general anesthesia under sevoflurane;
- parents or legal guardians of children who volunteered to participate in the trial; And signed the informed consent form.
You may not qualify if…
- Congenital malformation or other genetic conditions that are thought to affect brain development ;
- History of severe heart, brain, liver, kidney and metabolic diseases ;
- Premature infants (≤32 weeks);
- Upper respiratory tract infection in the last two weeks.
Where it is running
- The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University — Wenzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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