A Study To Characterize Mass Balance Of [14C] HDM1002 in Chinese Healthy Subjects
Recruiting now · Phase 1
Conditions studied: Healthy Adult Subject
In brief
In this study, a single dose of \[14C\] radiolabelled HDM1002 will be administered orally. The main purpose of this study is to find out how much of HDM1002 and its metabolites pass from blood into urine and feces, and characterize the metabolic profile and routes of excretion of oral \[14C\] HDM002.
Key facts
- Study ID
- NCT06576401
- Run by
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
- People needed
- 10
- Starts
- 2024-08-27
- Expected to finish
- 2024-12-01
- Last updated by the study team
- 2024-09-04
Who can join
Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Male, healthy adult;
- Age of 18 to 45 years old (both inclusive);
- Body mass index (BMI) between 19.0- 32.0 kg/m2 (both inclusive) and body weight no less than 50.0 kg.
You may not qualify if…
- Clinically significant diseases at the time of screening;
- History or family history of medullary thyroid carcinoma, thyroid C-cell hyperplasia, or multiple endocrine neoplasia type 2 (MEN2), or calcitonin ≥ 35 ng/L during the screening period;
- History of chronic pancreatitis or acute pancreatitis within 3 months prior to screening;
- History of acute cholecystitis attack within 3 months prior to screening;
- Participant judged by investigator has dysphagia, diseases or conditions that affect gastric emptying or affect the absorption of nutrients in the gastrointestinal tract, such as bariatric surgery or other gastrectomy, irritable bowel syndrome, dyspepsia, etc.;
- Any of the following: habitual constipation or diarrhea, hemorrhoids or accompanied by perianal disease, irritable bowel syndrome, inflammatory bowel disease, etc;
- Use of any prescription medication, over-the-counter medication, Chinese herbal medicine or food supplement within 14 days or 5 half-lives (whichever is longer) prior to the screening period;
- Patients with any abnormal and clinically significant examinations in given comprehensive physical examination;
- History of drug abuse (e.g., morphine, ketamine, tetrahydrocannabinolic acid, metham phetamine, methylenedioxyamphetamine, cocaine) or positive urine drug test during the screening period;
- Positive for hepatitis B surface antigen or E antigen, hepatitis C virus antibody IgG (Anti-HCV IgG), human immunodeficiency virus antigen/antibody combination test (HIV-Ag/Ab) and Treponema pallidum antibody during the screening period.
- Engaged in working conditions requiring long-term exposure to radioactivity; or significant radioactive exposure ( ≥ 2 CT chest/abdomen tests, or ≥ 3 all other types of X-rays test) within 1 year prior to the trail, or participated in radio-label trails;
Where it is running
- The First Affiliated Hospital of Soochow University — Suzhou, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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