Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies
Recruiting now
Conditions studied: Atrial Fibrillation, Ventricular Tachycardia, Premature Ventricular Contraction
In brief
The goal of this observational study is to determine if electrophysiologic mapping and cardiac MRI can help identify patients that have genetic forms of cardiomyopathy that are at high risk for development of dangerous ventricular arrhythmias. The investigators aim to study: 1. the prevalence and mechanism of inducible ventricular tachycardia 2. pace-mapping to define the site of origin of ventricular arrhythmias 3. voltage mapping to define low voltage scar substrate in the basal LV to determine the risk of development of ventricular arrhythmias in patients with genetic forms of cardiomyopathy. Participants will undergo cardiac MRI before their scheduled procedure and voltage mapping during their scheduled procedure as part of data collection.
Key facts
- Study ID
- NCT06575881
- Run by
- Vanderbilt University Medical Center
- People needed
- 200
- Starts
- 2023-12-13
- Expected to finish
- 2029-12-01
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 and older
- Diagnosed with AF, frequent PVCs, or VT before age 60
- Scheduled for catheter-based AF ablation (de-novo or repeat) OR catheter-based PVC ablation OR catheter-based VT ablation
- Able to provide written, informed consent
- P/LP variant in TTN or other CM gene (cases) or identified as a genotype-negative control.
You may not qualify if…
- Diagnosed with a genetic CM or arrhythmia syndrome prior to ablation procedure
- VUS in 'possibly pathogenic' subgroup (control group only)
- Previous PVC or VT ablation
- LVEF <20%
- Prosthetic mitral or aortic valve
- Contraindication to heparin
- Prior myocardial infarction
Where it is running
- Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.