Rectus Sheath Block for Analgesia After Gynecological Laparotomy

Completed · Phase 4

Conditions studied: Gynecologic Surgical Procedures

In brief

Thirty subjects undergoing laparotomy for Gynecologic oncology surgery will be prospectively enrolled and will receive a bilateral rectus sheath block (RSB) under ultrasound guidance using 133 mg liposomal bupivacaine and 20 ml bupivacaine 0.25% per side. Cases will be matched in a 1:2 ratio by age, race, insurance status and duration of surgery with historical controls who received postoperative analgesia using thoracic epidural analgesia.

Key facts

Study ID

NCT06575699

Run by

Duke University

People needed

90

Starts

2024-10-10

Expected to finish

2025-11-28

Last updated by the study team

2026-02-02

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥18 years presenting for a laparotomy for Gynecologic malignancy with a vertical incision.
• ASA Classification II or III.
• English speaking patients

You may not qualify if…

• BMI >50 kg/m2.
• Chronic pain or chronic opioid therapy.
• Allergy or contraindication to local anesthetics or any component of the multimodal analgesic regimen (NSAIDs and acetaminophen)

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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