An Observational Study of Predictors and Outcomes of Lung Cancer in Never-smokers in the UK

Recruiting now

Conditions studied: Lung Cancer

In brief

The goal of this observational study is to improve the early detection of lung cancer in adults who have smoked less than 100 tobacco cigarettes ("never-smokers") in the United Kingdom. The main questions it aims to answer are: * To describe characteristics such as demographics, co-morbidities and environmental exposures * To describe participant pathways including presentation mode and symptoms to understand if earlier diagnosis would be possible * To describe participant outcomes such as cancer stage, treatment and mortality * To quantitatively or qualitatively measure modifiable and non-modifiable factors that may be associated with LCINS including environmental measures, blood tests and genomic data. Participants will currently have no change to their usual care.

Key facts

Study ID

NCT06575439

Run by

University College London Hospitals

People needed

225

Starts

2024-09-17

Expected to finish

2029-09-01

Last updated by the study team

2024-12-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult participants from age of 18 who are diagnosed or treated with primary lung cancer through radiology or histology at any participating study site

You may not qualify if…

• Participants who have ever smoked cigarettes or tobacco will be excluded; this is defined as:
• More than 100 cigarettes or 75g tobacco in their lifetime
• Those who have received a prescription for nicotine replacement therapy
• For prospective participants, those who cannot consent will be excluded

Where it is running

• University College London Hospital — London, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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