Dexmedetomidine Reduces Sevoflurane MAC-BAR During Pneumoperitoneum

Recruiting now · Phase 4

Conditions studied: Laparoscopic Cholecystectomy

In brief

This clinical trial aims to learn the impact of dexmedetomidine on the minimum alveolar concentration blunting the adrenergic response (MAC-BAR) of sevoflurane to carbon dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. It will also learn about the effect of dexmedetomidine on hemodynamic parameters. The main questions are: * Does dexmedetomidine reduce the MAC-BAR of sevoflurane required to suppress the sympathetic response to carbon dioxide pneumoperitoneum? * Would dexmedetomidine administration dose-dependently reduce the minimum alveolar concentration blunting the adrenergic response of sevoflurane required to suppress the sympathetic response to carbon dioxide pneumoperitoneum? Researchers will compare low-dose dexmedetomidine to high-dose dexmedetomidine to see if dexmedetomidine works to treat postoperative negative behavior change and emergence delirium. Participants will: * Take intravenous dexmedetomidine or 0.9% saline (a look-alike substance that contains no drug) * Study drug infusions were initiated 15 minutes prior to anesthesia induction, allowing a minimum of 30 minutes to elapse before surgical incision to achieve steady-state plasma and brain concentrations.

Key facts

Study ID

NCT06575179

Run by

Fujian Provincial Hospital

People needed

90

Starts

2024-09-02

Expected to finish

2024-12-30

Last updated by the study team

2024-10-01

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1. Aged 18-45 years.
• 2. American Society of Anesthesiologists (ASA) grade I - II.
• 3. Patients undergoing elective laparoscopic cholecystectomy.

You may not qualify if…

• 1. Inability to provide informed consent;
• 2. History of chronic pain or substance abuse;
• 3. Pregnancy;
• 4. Body mass index (BMI) ≥ 30 kg/m2;
• 5. Known allergies to the study medications;
• 6. Intake of medications within the last 72 hours that potential interfere with the determination of the MAC-BAR;
• 7. Any other condition deemed exclusionary by the investigators.

Where it is running

• Fujian Provincial Hospital — Fuzhou, Fujian, China (enrolling)

Full record on ClinicalTrials.gov

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