Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

Recruiting now

Conditions studied: Hypophosphatasia

In brief

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Key facts

Study ID

NCT06574282

Run by

University of Bonn

People needed

720

Starts

2024-08-25

Expected to finish

2027-09-01

Last updated by the study team

2025-02-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Written informed consent
• Age > 18 years
• Clinical suspicion of hypophosphatasia
• Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

You may not qualify if…

• Failure to meet the inclusion criteria listed above

Where it is running

• Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn — Bonn, North Rhine-Westphali, Germany (enrolling)

Full record on ClinicalTrials.gov

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