Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy

Starting soon · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Carbon Monoxide Poisoning, Carbon Monoxide Intoxication, Carbon Monoxide Encephalopathy, Carbon Monoxide-induced Parkinsonism

In brief

Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.

Key facts

Study ID

NCT06574048

Run by

University of Nebraska

People needed

20

Starts

2026-07-01

Expected to finish

2028-01-01

Last updated by the study team

2026-04-17

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute CO poisoning, intentional or non-intentional exposure, receiving HBO treatment during hospitalization
• Age >18 years
• Nebraska Medicine admission

You may not qualify if…

• Mechanical ventilation
• No hospital admission or admission to hospital Critical Care Medicine Service
• Allergy to dexamethasone
• Pre-Existing neurological condition confounding outcome determination

Where it is running

• Nebraska Medicine, Hyperbaric Medicine Program, Clarkson Tower — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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