Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Healthy, Recreationally Active Adults

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Ageing Well, Neuromuscular Function

In brief

The main aim of this study is to understand if chronic supplementation (12 weeks) of a milk fat globule membrane containing supplement, called bioactive whey protein concentrate, improves human muscle function greater than a placebo supplement within a cohort of healthy, recreationally active adults. Furthermore, we aim to investigate whether any potential benefits of milk fat globule membrane are influenced by age through the assessment of 2 distinct age subgroups (young and older). We hypothesise that neuromuscular function (strength and power) will increase from pre to post within the group that consumes bioactive whey protein concentrate but not the placebo group, with a greater increase in the older group compared to the young group.

Key facts

Study ID

NCT06573749

Run by

Loughborough University

People needed

96

Starts

2025-03-28

Expected to finish

2026-01-01

Last updated by the study team

2025-04-02

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-30 or 60-75 years old
• Male or female
• Healthy with no contraindications to exercise
• Classified as recreationally active (meet the government's guidelines for weekly physical activity - 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity)

You may not qualify if…

• Any injury, medical condition or symptom precluding the ability to complete strenuous exercise as identified by the health screen questionnaire and physical activity readiness questionnaire
• Uncontrolled hypertension (blood pressure of 140/90 mmHg or higher) as identified by recording resting blood pressure
• Neuromuscular or musculoskeletal disease
• Occurrence of a severe injury to the lower limbs or back within the previous 6 months (time loss of > 21 days of normal activity)
• Occurrence of a minor injury to the lower limbs or back within the previous month (time loss of >1 day of normal activity)
• Do not meet the government guidelines of minimum weekly physical activity as revealed by the IPAQ-SF
• Allergic to dairy or pea, or lactose intolerant
• Complete greater than 6 hours structured exercise per week as revealed by the exercise and physical activity form
• Consumption of supplements that may confound the results of the present study within the previous 3 months (includes any form of protein supplement, creatine, pre-workout supplements, any form of testosterone supplement, amino acids, beta-alanine, beta- hydroxy-beta-methylbutyrate (HMB), fish or krill oil, collagen supplements, any choline- containing supplement, or any phospholipid-containing supplement) as highlighted by the health screen questionnaire
• Taking anticoagulants or antiplatelet drugs
• Use of antidepressant/anti-anxiety medication
• Having a blood borne virus, or a partner who has a blood-borne virus
• Extreme diet classified as identified by the food-frequency questionnaire

Where it is running

• Loughborough University — Loughborough, Leicestershire, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

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