Thoracic Fluid Content During Stabilization and Therapeutic De-escalation in Septic Shock

Recruiting now

Conditions studied: Sepsis, Septic Shock, Hemodynamic Instability, Fluid Overload

In brief

In ICU, fluid challenge represents one of the cornerstones of hemodynamic care. However, fluid overload due to an excessive and/or inappropriate fluid administration could be associated with morbidity or mortality. Unfortunately, there is currently no continuous non-invasive devices to monitor fluid content at bedside. Bio reactance is a non-invasive, rapid and continuous technology developed in order to measure body fluid compartment. Monitoring devices functioning with such technology are promising to evaluate fluid overload in ICU.

Key facts

Study ID

NCT06572995

Run by

University Hospital, Brest

People needed

50

Starts

2023-06-01

Expected to finish

2025-06-01

Last updated by the study team

2024-08-27

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult (Age >18 years old)
• Septic shock according to Sepsis-3 definition:
• A suspected or confirmed infection
• Persisting hypotension, despite adequate fluid resuscitation, requiring vasopressor to maintain a Mean Arterial Pressure (MAP) ≥ 65 mmHg
• Lactate level > 2 mmol/l
• Predictive ICU length of stay > 3 days

You may not qualify if…

• Admission in ICU for more than 3 days
• Refusal to participate
• Moribund patients
• Decision of therapeutic withdrawal
• Curators

Where it is running

• Chu Brest — Brest, France (enrolling)
• Hegp - Aphp — Paris, France

Full record on ClinicalTrials.gov

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