Non-invasive Phrenic Nerve Stimulation in ARDS Patient

Recruiting now · Not applicable

Conditions studied: ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury

In brief

Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.

Key facts

Study ID: NCT06572280
Run by: Southeast University, China
People needed: 10
Starts: 2024-08-01
Expected to finish: 2025-01-30
Last updated by the study team: 2024-08-27

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult ARDS patients undergoing controlled mechanical ventilation
The duration of endotracheal intubation < 48 hrs

You may not qualify if…

Neurological condition affecting motor neuron or muscle (e.g. ALS)
Paralysis of the phrenic nerve
Proven or suspected spinal cord injury
Conditions that limit diaphragm movement
Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator)
Patients with implanted medical pumps
Pregnancy
Patients with skin lesions, infections or strictures in throat/neck area
Patients with metallic implants
Refusal to sign informed consent

Where it is running

Zhongda Hospital, School of Medicine, Southeast University — Nanjing, Jiangsu, China (enrolling)

Full record on ClinicalTrials.gov

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