Efficacy of Dupilumab Added to Medium Dose Inhaled Corticosteroid/Long-acting Beta-agonist (ICS/LABA) in Comparison to ICS Dose Escalation to High Dose ICS/LABA in Adolescent and Adult Patients With Uncontrolled Asthma
Running, not enrolling · Phase 4 · Has a placebo group
Conditions studied: Asthma
In brief
This study is researching a drug called dupilumab. The study is focused on patients who have uncontrolled asthma. Asthma is a condition where the airways narrow and swell, making it difficult to breathe. Uncontrolled asthma means that patients are still having frequent symptoms while taking their current asthma medication. The aim of the study is to see which regimen is more effective: taking dupilumab with an inhaled asthma medication or only taking a higher dose of the inhaled asthma medication. The type of asthma medication that will be used is a combination inhaled corticosteroid and long-acting beta-agonist (referred to as an ICS/LABA). Some patients may also receive an additional asthma medication called a long-acting muscarinic antagonist (referred to as a LAMA) if they are already receiving a LAMA. The study is also looking at: • What side effects may happen from taking dupilumab
Key facts
- Study ID
- NCT06572228
- Run by
- Regeneron Pharmaceuticals
- People needed
- 120
- Starts
- 2024-08-26
- Expected to finish
- 2027-04-24
- Last updated by the study team
- 2026-05-22
Who can join
Age: 12 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Modena Allergy & Asthma, Inc. — La Jolla, California, United States
- Antelope Valley Clinical Trials — Lancaster, California, United States
- Ark Clinical Research, LLC — Long Beach, California, United States
- Newport Native Md, Inc. — Newport Beach, California, United States
- Childrens Hospital of Orange County Main Campus — Orange, California, United States
- Raffi Tachdjian MD, Inc. — Santa Monica, California, United States
- Bensch Clinical Research — Stockton, California, United States
- Integrated Research of Inland, Inc. — Upland, California, United States
- Allianz Research Institute — Westminster, California, United States
- National Jewish Health — Denver, Colorado, United States
- St Francis Medical Institute — Clearwater, Florida, United States
- Florida Lung, Asthma and Sleep Specialists (FLASS) - Celebration — Kissimmee, Florida, United States
- Clinical Site Partners, LLC DBA Flourish Research — Winter Park, Florida, United States
- Treasure Valley Medical Research — Boise, Idaho, United States
- Sneeze Wheeze and Itch Associates — Normal, Illinois, United States
- Asthma and Allergy Center of Chicago — River Forest, Illinois, United States
- Endeavor Health, Skokie Campus — Skokie, Illinois, United States
- University of Kansas Medical Center — Kansas City, Kansas, United States
- Bluegrass Allergy Research — Lexington, Kentucky, United States
- Family Allergy and Asthma Research Institute — Louisville, Kentucky, United States
- Allergy & Asthma Specialists, P.S.C. — Owensboro, Kentucky, United States
- Paul A. Shapero, M.D. — Bangor, Maine, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Michigan Medicine — Ann Arbor, Michigan, United States
- Kern Research, Inc — Bakersfield, California, United States
Full record on ClinicalTrials.gov
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