The Effects of Topical Almond Oil and Tretinoin on Facial Wrinkles
Recruiting now · Not applicable
Conditions studied: Collagen Degeneration, Wrinkle, Pigmentation, Elastic Skin, Sebum Deficiency
In brief
Investigate the topical use of almond oil, almond oil augmented with 0.5% vitamin E, 0.025% tretinoin oil augmented with castor oil on the appearance of facial fine lines and wrinkles, pigmentation, hydration, trans-epidermal water loss, and sebum excretion rate.
Key facts
- Study ID
- NCT06571721
- Run by
- Integrative Skin Science and Research
- People needed
- 90
- Starts
- 2024-07-22
- Expected to finish
- 2025-07-22
- Last updated by the study team
- 2024-08-28
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Post-menopausal women of Fitzpatrick skin types 1, 2, and 3
- Individuals with facial fine lines and wrinkles
You may not qualify if…
- Individuals who are pregnant or breastfeeding
- Prisoners
- Adults unable to consent
- Those with a nut allergy or tocopherol allergy
- Current smokers, those that have smoked within the past year, and former smokers with greater than a 10-pack- year history of smoking
- Those with an autoimmune photosensitive condition or a known genetic condition with a deficiency in collagen production (such as Ehlers-Danlos syndromes)
- Those who have undergone any cosmetic procedures to the face in the 3 months prior to enrollment in the opinion of the investigator. People that have undergone deeper chemical peels (TCA based peels) within 1 year prior to enrollment
- Individuals who are unwilling to discontinue vitamin E containing supplements and food sources such as all nuts, sunflower seeds or sunflower oil during the washout and intervention
- Individual who are unwilling to discontinue topical cosmetic products during the duration of the study or unwilling to undergo a 2-week washout of topicals that are known to modulate collagen and pigment:
- Retinoids such as tretinoin, adapalene, retinol, except as provided by the study.
- Antioxidant ingredients such as vitamin C or vitamin E.
- Pigment reducing agents such as hydroquinone, azelaic acid, kojic acid, or a retinoid except for the retinol that is provided in this study.
- Topicals that contain a nut oil or nut extract as part of their ingredient list.
Where it is running
- Integrative Research Institute — Sacramento, California, United States (enrolling)
Full record on ClinicalTrials.gov
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