Growth Hormone Resistance of Beta-cells A

Recruiting now

Conditions studied: Gestational Diabetes, Obesity, Healthy

In brief

The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.

Key facts

Study ID

NCT06571487

Run by

University of Missouri-Columbia

People needed

30

Starts

2025-10-22

Expected to finish

2030-09-01

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Singleton, full term pregnancy within the past 5 years
• Body mass index ≥18.5 kg/m2 and <45.0 kg/m2
• Group specific inclusion criteria:
• Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
• Control Group: no history of gestational diabetes

You may not qualify if…

• Pregnant, planning to become pregnant during the study, or breastfeeding
• Current diagnosis or history of type 1 or type 2 diabetes
• Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
• History of bariatric surgery
• Known, uncontrolled hypothyroidism
• History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
• Current cancer or cancer that has been in remission less than 5 years
• First degree relative with diabetes diagnosis
• Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
• Alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
• Greater than 3% weight loss within three months of screening or engaged in regular (≥3 days per week), continuous moderate- or high-intensity exercise of ≥30 min duration
• Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent

Where it is running

• University of Missouri School of Medicine — Columbia, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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