A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

Recruiting now · Phase 2

Conditions studied: Systemic Lupus Erythematosus, Active Refractory Rheumatoid Arthritis

In brief

The main objective is to assess the safety and tolerability of inebilizumab in adult participants with active and refractory systemic lupus erythematosus (SLE) with nephritis (Subprotocol A) and to assess the safety and tolerability of subcutaneous (SC) blinatumomab in adult participants with active and refractory SLE with and without nephritis (Subprotocol B Part A) and in adult participants with active refractory rheumatoid arthritis (RA) (Subprotocol C Part A). The trial will also assess the efficacy of SC blinatumomab in adult participants with active and refractory SLE with and without nephritis (Subprotocol B Part B and Subprotocol C Part B).

Key facts

Study ID

NCT06570798

Run by

Amgen

People needed

220

Starts

2025-07-16

Expected to finish

2028-08-06

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subprotocol A and B: Diagnosis of SLE according to 2019 European League Against Rheumatism and the American College of Rheumatology (ACR) classification criteria.
• Subprotocol A and B: Participant must be positive for at least one of the following autoantibodies at screening (performed by central laboratory) or through documented history:
• Antinuclear antibodies (ANA) ≥ 1:80
• Anti-double stranded deoxyribonucleic acid (anti-dsDNA) antibodies elevated to above normal range (ie, positive results)
• AntiSmith antibodies elevated to above normal (ie, positive results).
• Subprotocol A and B (Subgroup 1): Active, biopsy-proven, proliferative LN demonstrating class III or class IV with or without co-existing features of Class V LN (or pure Class V LN for Subprotocol B only) according to 2018 International Society of Nephrology/Renal Pathology Society (ISN/RPS) criteria. The local biopsy report will be used.
• Subprotocol A and B: SLE Disease Activity Index 2K ≥ 6.
• Subprotocol A and B (Subgroup 1): Inadequate response, loss of response or intolerance to at least 1 therapy (Subprotocol A) or 2 immunosuppressive therapies (Subprotocol B Subgroup 1) at the maximally tolerated doses as recommended by the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines (KDIGO, 2024). Inadequate response is defined as: UPCR ≥ 1.0 mg/mg.
• Subprotocol B (Subgroup 2): Refractory SLE participants with inadequate response to multiple therapies (excluding hydroxychloroquine or corticosteroids) and have failed either a biologic agent or cyclophosphamide.
• Subprotocol B (Part B Subgroup 2): British Isles Lupus Assessment Group (BILAG)-2004 level A disease in 1 organ system or BILAG-2004 level B disease in ≥ 2 organ systems
• Subprotocol B (Part B Subgroup 2): Physician Global Assessment (PGA) ≥ 1
• Subprotocol A and B: If receiving any of the following medications, participants must be on these doses prior to Day 1:
• Prednisone dose ≤ 20 mg/day (or its equivalent in other corticosteroid forms) and at a stable dose for 5 days
• Hydroxychloroquine dose ≤ 400 mg/day and at a stable dose for 4 weeks. Other equivalent antimalarials (chloroquine, quinacrine) are also accepted at a stable dose for 4 weeks.
• MMF dose ≤ 3 g/day or MPA dose ≤ 2160 mg/day and at a stable dose for 2 weeks.
• AZA dose ≤ 2 mg/kg/day and at a stable dose for 2 weeks.
• Methotrexate > 25 mg/week and at a stable dose for 2 weeks
• Leflunomide > 20 mg/day and at a stable dose for 2 weeks
• Dapsone > 300 mg/day and at a stable dose for 2 weeks.
• Subprotocol C (Part A and Part B): Diagnosis of RA according to the 2010 ACR/European Alliance of Associations for Rheumatology (EULAR) classification criteria.
• Subprotocol C (Part A and Part B): Moderate to severe disease activity as defined by DAS28-CRP > 3.2 with ≥ 3 swollen joints and ≥ 3 tender joints (based on 28 joint counts) at screening.
• Subprotocol C (Part A and Part B): Refractory disease defined as:
• Active disease despite having received treatment with:
• at least 1 conventional synthetic disease-modifying antirheumatic drug (csDMARD), AND
• at least 2 biologic disease-modifying antirheumatic drugs (bDMARDs) of different mechanisms of action OR 1 bDMARD and at least 1 targeted synthetic disease-modifying antirheumatic drugs (tsDMARD).

You may not qualify if…

• Subprotocol A, B and C: Receipt of a live and/or live attenuated vaccine within 4 weeks prior to first dose of trial drug, during the treatment period, or until B-cell repletion after the end of the treatment period. Administration of inactivated (killed) vaccines is acceptable.
• Subprotocol A and B: Estimated glomerular filtration rate (eGFR) of < 30 mL per minute per 1.73 m\^2 of body surface area (calculated using the Modification of Diet in Renal Disease [MDRD] formula, with screening laboratory results for serum creatinine value).
• Subprotocol A and B: Significant likely irreversible organ damage related to SLE (eg, end-stage renal disease [ESRD]).
• Subprotocol A and B: Any acute, severe lupus related flare during screening that needs immediate treatment.
• Subprotocol A and B: A previous kidney transplant or planned transplant within trial treatment period.
• Subprotocol A and B: History of or current renal diseases (Parts A and B, Subgroup 1) that in the opinion of the investigator could interfere with the LN assessment and confound the disease activity assessment (eg, diabetic nephropathy).
• Subprotocol A: Renal biopsy showing pure class V.
• Subprotocol B: Active CNS Lupus within one year prior to screening.
• Subprotocol B and C: History or presence of clinically relevant central nervous system (CNS) pathology or event such as seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, or organic brain syndrome.
• Subprotocol C: Prior history of current inflammatory joint disease other than RA including but not limited to SLE, mixed connective tissue disorder, scleroderma, polymyositis, or significant systemic involvement secondary to RA (eg, vasculitis, pulmonary fibrosis, or Felty's syndrome).
• Subprotocol C: Functional Class IV as defined by the ACR classification of functional status in RA.
• Subprotocol A, B and C: Receipt of the following medications or treatments at any time prior to Day 1:
• B-cell directed CAR T-cell and T-cell engager therapies
• Total lymphoid irradiation
• Bone marrow transplant
• T-cell vaccination therapy
• Natalizumab

Where it is running

• Hopital Europeen Georges Pompidou — Paris, France (enrolling)
• HonorHealth Research and Innovation Institute — Scottsdale, Arizona, United States (enrolling)
• Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot — Lyon Cédex 3, France (enrolling)
• Hopital Cochin — Paris, France (enrolling)
• Bioresearch Partner Coral Terrace — South Miami, Florida, United States (enrolling)
• University Medical Center New Orleans — New Orleans, Louisiana, United States (enrolling)
• University of Colorado — Aurora, Colorado, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States (enrolling)
• Northwell Health — Great Neck, New York, United States (enrolling)
• Hopital de la Conception — Marseille, France (enrolling)
• Columbia University Medical Center — New York, New York, United States (enrolling)
• University of Rochester Medical Center — Rochester, New York, United States (enrolling)
• MetroHealth Medical Center — Cleveland, Ohio, United States (enrolling)
• Cleveland Clinic Foundation — Cleveland, Ohio, United States (enrolling)
• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Seattle Rheumatology Associates — Seattle, Washington, United States (enrolling)
• Linear Clinical Research Limited — Perth, Western Australia, Australia (enrolling)
• Cliniques Universtaire Saint Luc Universite Catholique de Louvain — Brussels, Belgium (enrolling)
• Universitair Ziekenhuis Gent — Ghent, Belgium (enrolling)
• Universitair Ziekenhuis Leuven - Campus Gasthuisberg — Leuven, Belgium (enrolling)
• Centre Hospitalier Universitaire de Liege - Sart Tilman — Liège, Belgium (enrolling)
• Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre — Le Kremlin-Bicêtre, France (enrolling)
• Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez — Lille, France (enrolling)
• Centre Hospitalier Universitaire de Lyon- Hopital Edouard Herriot — Lyon, France (enrolling)
• Centre Hospitalier Universitaire de Strasbourg - Nouvel Hopital Civil — Strasbourg, France (enrolling)

Full record on ClinicalTrials.gov

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