Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals

Recruiting now · Not applicable

Conditions studied: Dental Pulp Necroses

In brief

The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.

Key facts

Study ID

NCT06569329

Run by

Abhishek Parolia

People needed

90

Starts

2024-08-20

Expected to finish

2026-08-01

Last updated by the study team

2025-09-17

Who can join

Age: 18 and older, up to 95. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of pulp necrosis with apical periodontitis (AP) confirmed by pulp tests, clinical and radiographic evidence.
• Tooth with no response to cold and electric pulp testing (done at screening).
• Single canalled premolars with intact pulp chamber walls.
• Patient must be 18 years of age or older

You may not qualify if…

• Teeth with vital pulp.
• Teeth with incomplete root formation (immature with apical periodontitis).
• Teeth with extensive crown destruction.
• Teeth with previous endodontic treatment or intervention (pulp debridement).
• Teeth with acute/ chronic apical abscess.
• Teeth with internal or external resorption.
• Teeth with non-odontogenic facial pain.
• Teeth with periodontal pockets deeper than 4 mm.
• Teeth with advanced untreated periodontal disease or recent periodontal surgery.
• Teeth with mobility score greater than 2.
• Teeth with a fracture or visible crack.
• Patients with diabetes or immune compromised conditions.
• Patients who received systemic antibiotics within the last 3 months.
• Patients taking corticosteroids.
• Patients who are pregnant.

Where it is running

• University of Iowa College of Dentistry and Dental Clinics — Iowa City, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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