Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation

Recruiting now · Not applicable

Conditions studied: Socket Preservation

In brief

The aim of the study is to evaluate radiographic ridge width change following autogenous demineralized dentin graft (ADDG) and i-PRF addition with and without vitamin C (AA) for post extraction socket preservation. The main question is: In patient with non-restorable teeth, does adding vitamin C to dentin graft and i-PRF affect the radiographic ridge width of post extraction sockets? Intervention group: Alveolar ridge preservation using vitamin C (AA) with autogenous demineralized dentin graft combined with i-PRF. Adding vitamin C to dentin graft and i-PRF might aid in reducing the dimensional changes, since it increases osteoblast proliferation and viability during socket preservation. Layers of osteoblast cell morphology can be seen at day 11 with the presence of 25mM of vitamin C. By adding vitamin C to i-PRF we can add the advantages of improving soft tissue quality as well. Control group: Alveolar ridge preservation using autogenous demineralized denting graft combined with i-PRF. Dentin particle can be used as an excellent autogenous graft material to replace other autogenous graft materials, it can be used in socket preservation. as it enhances bone formation, and has shown an ability to maintain the alveolar ridge dimensions because of its osteo-conductive properties. Moreover, dentin graft is used as a cost-effective grafting material during socket preservation. The initial therapy consists of periodontal treatment (phase I therapy) including supragingival scaling, subgingival debridement if needed, adjustment of faulty restoration and polishing. The mechanical plaque control instructions for each patient include brushing and interdental cleaning techniques. Flapless and atraumatic tooth extraction will be initiated, Then the sockets will be carefully packed with the allocated graft material that are shaped to match the individual size and contours of each socket. Once the grafts are properly adapted to the sockets, they will be covered with the corresponding graft material, and an absorbable gelatin sponge (gelfoam) will be used for socket and graft material coverage and secured using an internal crisscross knot using 5-0 monofilament polypropylene suture material.

Key facts

Study ID

NCT06569264

Run by

Cairo University

People needed

26

Starts

2025-11-04

Expected to finish

2026-02-28

Last updated by the study team

2025-12-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Inclusion criteria:
• ≥ 18 years of age.
• Single extraction of non-molar teeth with periodontally healthy adjacent teeth.
• Non-contributory medial history.
• Non- restorable teeth indicated for extraction.
• Requiring alveolar preservation after tooth extraction prior to placement of dental implant.
• Participants that are eligible for immediate implantation, yet having factors that are hindering these patients from immediate placement of an implant at the time of extraction (ex: Financial related factors - psychological psychological factors - time related factors).
• Cooperative patients who are willing to commit for 3 months follow up.

You may not qualify if…

• Pregnant female.
• Acute infection at extraction site.
• Systemic conditions affecting healing (e.g., diabetes, medications as bisphosphonates...)
• A participant who had radiotherapy or chemotherapy.
• Psychiatric patient, or with a learning disability, or unable to give consent.

Where it is running

• Faculty of Dentistry, Cairo University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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