Predictive Value of Myelodysplastic Syndrome Stem Cells Determined by Multiparameter Flow Cytometry

Recruiting now

Conditions studied: Myelodysplastic Syndromes

In brief

Presently, multiparameter flow cytometry (MFC) and polymerase chain reaction (PCR) have been used for disease load, including measurable residual disease (MRD), monitoring in patients with myelodysplastic syndrome (MDS). MFC is the most commonly method for disease load evaluation. In patients with acute myeloid leukemia, leukemia stem cells (LSCs) determined using MFC for leukemia load and MRD detection is superior to traditional MFC method. In the investigators previous single center study, the investigators demonstrated that detection of disease load, including MRD, by MFC in patients with MDS-EB is superior to predict outcomes after allogeneic stem cell transplantation. Here, the investigators will perform a multi-center, prospective clinical trial to investigate the predictive values of MDS-SC in patients with MDS-EB who received allografting.

Key facts

Study ID

NCT06569095

Run by

Peking University People's Hospital

People needed

163

Starts

2024-12-09

Expected to finish

2027-12-18

Last updated by the study team

2026-02-24

Who can join

Age: 15 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with Myelodysplastic syndromes;
• Between 15 and 70 years old;
• Subjects are able to provide written informed consent.

You may not qualify if…

• Subjects who cannot comply with the study;
• Patient has severe cardiac (ejection fraction <50%), hepatic (total bilirubin >34μmol/L, ALT, AST >2x upper limit of normal) or renal (blood creatinine >130μmol/L) disease；
• Uncontrolled serious infection;
• Other conditions that do not tolerate transplantation or other therapies.

Where it is running

• Chinese PLA General Hospital — Beijing, China (enrolling)
• Peking University People's Hospital — Beijing, China (enrolling)
• Wuhan TongJi Hospital — Wuhan, China (enrolling)
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, China (enrolling)

Full record on ClinicalTrials.gov

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