Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Starting soon · Phase 4

Conditions studied: Infection, Surgical Site

In brief

The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short versus long-term prophylaxis with four study arms: 1) cefazolin short-term, 2) cefazolin long-term, 3) cefazolin plus vancomycin short-term and 4) cefazolin plus vancomycin long-term.

Key facts

Study ID

NCT06567808

Run by

Hamilton Health Sciences Corporation

People needed

38000

Starts

2026-03-01

Expected to finish

2028-07-30

Last updated by the study team

2026-03-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (≥18 years of age) undergoing open-heart surgery (i.e. sternotomy, including minimally-invasive surgical techniques through mini-sternotomies)

You may not qualify if…

• On systemic antibiotics or with an active bacterial infection at the time of surgery
• Previously enrolled in this trial
• Known to be colonized with methicillin-resistant staphylococcus aureus (MRSA). Where it is unethical to not administer glycopeptides.
• Beta-lactam or vancomycin allergy precluding the use of cefazolin or vancomycin, respectively
• Participation in other studies that may interfere with this trial.
• Patients undergoing cardiac transplant

Full record on ClinicalTrials.gov

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