CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs

Running, not enrolling · Not applicable

Conditions studied: Ventral Hernia

In brief

Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.

Key facts

Study ID

NCT06565546

Run by

University of Florida

People needed

100

Starts

2025-01-29

Expected to finish

2026-10-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 18 years age undergoing a ventral hernia repair (VHR) ≥1.5 cm in diameter with mesh.

You may not qualify if…

• ventral hernia <1.5 cm
• primary ventral hernia repair (VHR) without a mesh
• emergency operative procedure
• receiving chronic opioid therapy (defined as use of opioids on most days for >3 months)
• allergy to opioids
• women of childbearing potential who have a positive pregnancy result as part of their standard pre-surgical workup

Where it is running

• University of Florida Jacksonville — Jacksonville, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.