Comparative Assessment of Sleep Positive Airway Pressure Modalities (CASPAM)

Recruiting now · Not applicable

Conditions studied: Obstructive Sleep Apnea

In brief

Obstructive sleep apnea (OSA) has been one of the topmost global health problems. It is an underdiagnosed disease which have a huge burden on healthcare if left untreated. Almost 80-90% of adults are underdiagnosed of OSA Obesity primarily is one of the supreme risk factors for developing OSA. Globally, obesity cases have risen affecting almost two billion people. According to National Health and Morbidity Survey (NHMS) 2019, 1 in 2 adults in Malaysia were overweight or obese. Report from World Obesity Atlas 2023 predicts that adult obesity will rise 4.7% annually from 2020 - 2035, while child obesity will increase by 5.3% per year over similar timeline. Overweight individuals will have a significant economic impact on Malaysia's Gross Domestic Product (GDP) by 2035 by 2.8% which is estimated to be about RM 3.2 trillion. Sequalae of OSA is divided into two (cardiovascular-metabolic effect and neurocognitive effect). This group of patients are at high risk of developing hypertension, insulin resistance, dyslipidemia which then leads to pulmonary hypertension and heart failure. More importantly, from the neurocognitive point of view, persistent sleep deprivation will lead to poor concentration, impaired memory, personality changes affecting overall self-performance which can lead to depression and compromising safety as they have higher risk of work-related accidents.

Key facts

Study ID

NCT06564896

Run by

National University of Malaysia

People needed

50

Starts

2024-09-01

Expected to finish

2027-01-01

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥ 18 years.
• Patients diagnosed with moderate to severe OSA (based on AHI classification from sleep study performed).
• Patients who are able to understand and answer the questionnaire given.

You may not qualify if…

• Patients who are unable to give consent to the study.
• Patients who have been diagnosed with OSA and already on CPAP machine.
• Patients who had underlying Obesity Hypoventilation Syndrome (OHS).
• Patients who had underlying co-morbidities that worsen apnea symptoms, such as congestive cardiac failure, active malignancy, narcolepsy, active alcohol or drug abuse, treatment-refractory dementia, psychotic illness and active use of drugs that disturb the sleep architecture (i.e hypnotics or stimulants of central nervous system).

Where it is running

• National University of Malaysia, Faculty of Medicine — Cheras, Kuala Lumpur, Malaysia (enrolling)

Full record on ClinicalTrials.gov

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