A Cohort Study of Hereditary Ovarian Cancer Risk Prediction Models and Pathogenesis Exploration

Recruiting now

Conditions studied: Ovarian Neoplasms

In brief

The aim of this project is to establish a bidirectional multicenter cohort of hereditary ovarian cancer and to describe the clinicopathologic features of hereditary ovarian cancer patients in our country. The risk prediction model of ovarian cancer for Chinese was established by following-up analysis of clinical and pathological information, genetic test results and detailed family history, to predict the risk of cancer in first-degree relatives of carriers of pathogenic/suspected pathogenic mutations, and to guide the intervention management of high-risk population of cancer. The study will identify novel tumor-causing mutations/predisposing genes by gene sequencing in a special family with hereditary tumor.

Key facts

Study ID

NCT06564428

Run by

Peking University Third Hospital

People needed

1000

Starts

2024-01-01

Expected to finish

2026-12-31

Last updated by the study team

2025-06-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Epithelial ovarian cancer
• ≥18 years
• The pathological diagnosis was clear
• The genetic test showed germ line pathogenic/suspected pathogenic mutations (for mutation interpretation, refer to the American ACMG Classification Standards and Guidelines for Genetic Variation)

You may not qualify if…

• Non-epithelial ovarian cancer was confirmed by pathology
• No genetic test has been performed

Where it is running

• Peking University Third Hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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