Evaluation of Efficacy of Povetacicept in Adults With Immunoglobulin A Nephropathy (IgAN)

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Immunoglobulin A Nephropathy

In brief

The purpose of this study is to evaluate the efficacy of povetacicept in adult participants compared with placebo in reducing proteinuria and preserving renal function.

Key facts

Study ID

NCT06564142

Run by

Alpine Immune Sciences Inc, A Subsidiary of Vertex

People needed

605

Starts

2024-08-30

Expected to finish

2028-01-30

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arizona Kidney Disease and Hypertension Center - Thomas Office — Phoenix, Arizona, United States
• Arizona Kidney Disease and Hypertension Center - Tuscon — Tucson, Arizona, United States
• West Coast Kidney — Fremont, California, United States
• The Medical Research Group, Inc. (FRENOVA) — Fresno, California, United States
• CARE Institute - Carabello Kidney — Los Angeles, California, United States
• Providence Medical Foundation - Orange — Orange, California, United States
• National Nephrology Alliance Research — Riverside, California, United States
• UC Davis Health — Sacramento, California, United States
• Zuckerberg San Francisco General Hospital and Trauma Center — San Francisco, California, United States
• University of California San Francisco (UCSF) — San Francisco, California, United States
• Western Nephrology — Arvada, Colorado, United States
• Colorado Kidney Care — Denver, Colorado, United States
• Nephrology Associates Delaware Kidney (FRENOVA) — Newark, Delaware, United States
• South Florida Nephrology Group PA, Research Div. — Coral Springs, Florida, United States
• Dolphin Medical Research — Doral, Florida, United States
• Nephrology Associates of Central Florida — Hollywood, Florida, United States
• Tectum Medical Research, LLC — Hollywood, Florida, United States
• South Florida Research Institute — Lauderdale Lakes, Florida, United States
• Florida Kidney Physicians - Melbourne — Melbourne, Florida, United States
• Med-Care Research — Miami, Florida, United States
• Professional Research Center — Miami, Florida, United States
• Nephrology Associates of South Miami — Miami, Florida, United States
• On Health Research Center — Miami, Florida, United States
• Combined Research Orlando Phase I-IV — Orlando, Florida, United States
• Apogee Clinical Research, LLC — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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