Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy

Recruiting now · Phase 4 · Has a placebo group

Conditions studied: Opioid Consumption, Multimodal Analgesia, Acute Appendicitis, Complication of Treatment

In brief

Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the concentration of IL-6 (interleukin 6) and tumor necrosis factor alpha. In adult patients, the need for morphine in the perioperative period is reduced when magnesium infusion is used. In current guidelines for treatment of acute pain in children, magnesium sulfate may be considered as a co-analgetic. However, the strength of such a recommendation is low due to the lack of reliable scientific research confirming the effectiveness of magnesium infusion in the pediatric population. The aim of this study is to evaluate the efficacy of intravenous magnesium sulfate infusion on the opioid consumption, the circulatory, metabolic and hormonal response to intubation and surgical trauma during anesthesia for laparoscopic appendectomy in children.

Key facts

Study ID

NCT06563349

Run by

Medical University of Warsaw

People needed

188

Starts

2024-09-09

Expected to finish

2027-10-01

Last updated by the study team

2024-11-12

Who can join

Age: 2 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA (American Society of Anesthesiologists) physical status class 1E, 2E, 3E (E - emergency)
• Patients undergoing laparoscopic appendectomy

You may not qualify if…

• Allergy to the magnesium sulfate or the excipient
• Hypermagnesemia
• Renal failure (GFR <30 ml/min)
• Myasthenia gravis
• Preoperative atrioventricular block
• Hypotension
• The use of digitalis glycosides
• The use of oral anticoagulants
• ASA physical status class 4E or higher
• Chronic treatment with analgesics
• Legal guardians or patient refusal

Where it is running

• Uniwersity Clinic Centre of Medical Uniwersity of Warsaw — Warsaw, Poland (enrolling)

Full record on ClinicalTrials.gov

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