SY001 Targets Mesothelin in a Single-arm, Dose-increasing Setting in Subjects With Advanced Solid Tumors
Recruiting now · Not applicable
Conditions studied: Treatment Related Cancer, Ovarian Cancer
In brief
Single-arm, dose-increasing setting study of CAR macrophages in Mesothelin overexpressing solid tumors.
Key facts
- Study ID
- NCT06562647
- Run by
- Cell Origin Biotech (Hangzhou) Co., Ltd.
- People needed
- 2
- Starts
- 2023-04-12
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-02-13
Who can join
Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Patients with pathologically diagnosed advanced ovarian cancer/pancreatic cancer who have failed at least 1 prior lines treatment, and tumor tissue samples were positive for mesothlin IHC staining;
- According to the RECIST 1.1, there is measurable tumor lesions (non-lymph node lesion 10mm in length or lymph node lesion 15mm in diameter measured by CT or MRI, with scan layer thickness 5mm);
- Eastern Cooperative Oncology Group (ECOG) score of 2 and satisfactory major organ functions;
- Estimated life expectancy >3 months;
- Female patients of childbearing age must undergo a serum pregnancy test at screening and prior to pretreatment and the results must be negative, and are willing to use a very effective and reliable method of contraception within 1 year after the last study treatment.
You may not qualify if…
- Pregnant or lactating women;
- Any uncontrollable active infection, including but not limited to active tuberculosis, HBV infection;
- Patients who have a history of other mesothelin-targeting therapy;
- Patients who have a history of autoimmune disease;
- The investigator assessed that the patient was unable or unwilling to comply with the requirements of the study protocol.
Where it is running
- The First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (enrolling)
- Linyi Cancer Hospital — Linyi, China
Full record on ClinicalTrials.gov
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