Online Adaptive Radiotherapy for Cervical Cancer

Recruiting now · Phase 2

Conditions studied: Cervical Cancer

In brief

This study aims to evaluate the clinical efficacy and safety of online adaptive radiotherapy for cervical cancer patients received radical radiotherapy. By comparing with image-guided radiotherapy, the study explores the potential advantages of online adaptive radiotherapy in reducing treatment toxicity and improving local control.

Key facts

Study ID

NCT06562166

Run by

Peking Union Medical College Hospital

People needed

124

Starts

2024-09-05

Expected to finish

2028-12-01

Last updated by the study team

2026-01-08

Who can join

Age: 18 and older, up to 80. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 18-80 years old;
• Pathologically confirmed diagnosis of cervical cancer and pathological type of cervical squamous carcinoma;
• 2018 FIGO Stage Ib3, II, IIIB and IIIC1
• Proposed radical pelvic radiotherapy + concurrent sensitizing chemotherapy (platinum-based (cisplatin 30-40mg/m2 or carboplatin alone), starting concurrently in the first week, ≥5 courses)
• ECOG score 0-2
• Life expectancy greater than 6 months
• Ability to remain lying down for more than 30 minutes
• Patients were fully voluntary and autonomous and co-operated in signing the study informed consent form
• Complete blood count and basal metabolic indexes within 14 days before enrolment must meet the following requirements: NEUT ≥ 1.5*109/L, HGB ≥ 60g/L, platelets ≥ 100×109/, blood creatinine \<1.5 mg/dL. AST and ALT are within 2 times the upper limit of normal
• Must complete baseline assessments and investigations required before treatment before enrolment
• be eligible for regular follow-up

You may not qualify if…

• Have received radiotherapy or chemotherapy in the past
• Have undergone radical surgery for cervical cancer
• Have a previous history of malignant tumor
• Pregnant or lactating women
• Presence of other serious co-morbidities such as poorly controlled cardiovascular, urinary, digestive, respiratory, hematological and central nervous system diseases.

Where it is running

• Peking union medical college hospital — Beijing, China (enrolling)

Full record on ClinicalTrials.gov

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