Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

Recruiting now · Phase 3

Conditions studied: Peripheral T-Cell Lymphoma, Not Otherwise Specified, Angioimmunoblastic T-cell Lymphoma, Follicular T-Cell Lymphoma, Nodal Peripheral T-Cell Lymphoma With TFH Phenotype, Systemic Anaplastic Large Cell Lymphoma, Lymphoma, T-Cell, Peripheral, Lymphoma, T-Cell

In brief

A Phase 3, randomized, 2-arm, open-label, multicenter, stratified study of soquelitinib versus physician's choice standard of care (SOC) treatment (selected single agents) in participants with relapsed/refractory (R/R) peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), follicular helper T-cell lymphomas (FHTCLs), or systemic anaplastic large-cell lymphoma (sALCL).

Key facts

Study ID: NCT06561048
Run by: Corvus Pharmaceuticals, Inc.
People needed: 150
Starts: 2024-10-02
Expected to finish: 2028-12-01
Last updated by the study team: 2026-04-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adult participants ≥18 years of age on the day of signing the informed consent form.
Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2.
Histologically confirmed PTCL-NOS, FHTCLs or sALCL per The International Consensus Classification of Mature Lymphoid Neoplasms.
Progressed on, be refractory to, relapsed, or intolerant to standard therapy for their cancer. At least 1 but not more than 3 prior systemic therapies.
Fluorodeoxyglucose-avid disease by positron emission tomography and measurable disease of at least 1.5 cm by computed tomography, as assessed by the site radiologist.
Life expectancy >12 weeks.
Adequate organ function as determined by:
Absolute neutrophil count ≥ 1.0×10\^9/L (1000/mm3) (without receiving granulocyte-colony stimulating factor)
Platelet count ≥ 100×10\^9/L (without transfusion)
Hemoglobin ≥ 9.0 g/dL, without packed red blood cell transfusion within the last 1 week of starting study drug
Prothrombin time international normalized ratio and partial thromboplastin time ≤1.5 × upper limit of normal (ULN), unless participant is receiving anticoagulant therapy and prothrombin time or activated partial thromboplastin time is within therapeutic range of intended use of anticoagulants
Calculated creatinine clearance (CrCl) according to Cockcroft-Gault formula and based on ideal body weight or 24-hour urine CrCl ≥ 50 mL/minute
Total bilirubin ≤ 1.5 × ULN or direct bilirubin ≤ ULN for participants with total bilirubin levels > 1.5 × ULN. For participants with Gilbert's disease: ≤ 3.0 mg/dL or discussion with the Medical Monitor
Aspartate aminotransferase and alanine transaminase ≤ 2.5 × ULN (≤ 5 × ULN for participants with liver metastases)
Serum albumin > 2.5 g/dL
Serum calcium < 12 mg/dL or corrected serum calcium < ULN
Must have recovered from all AEs due to previous therapies to Grade ≤ 1 or baseline except for the following:
Grade ≤ 2 neuropathy
Alopecia and non-acute toxicities
If major received major surgery, then must have recovered adequately per the investigator from the toxicity and/or complications from the intervention prior to starting study treatment
Female participants of childbearing potential who are sexually active with a non-sterilized male partner must agree to use at least 1 highly effective method of contraception from the time of screening and must agree to continue using such precautions for 120 days after the last dose of study drug for participants who receive soquelitinib, or 6 months after the last dose for participants who receive either belinostat or pralatrexate.
Non-sterilized males who are sexually active with a female partner of childbearing potential must use a condom plus spermicide from Day 1 through 120 days after the last dose of study drug.

You may not qualify if…

Participants who have T-cell lymphoma with active central nervous system involvement.
Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the participant from participating in the study.
History of primary immunodeficiency or sold organ transplantation.
History of opportunistic infection within 30days of screening requiring active systemic treatment or active infection requiring IV therapy.
Any active infection requiring IV therapy.
History of invasive prior malignancy that required systemic therapy within last 3 years.
Any condition that confounds the ability to interpret data from the study.
Known to be positive for HIV, or positive test for chronic hepatitis B virus (HBV) infection (defined as positive hepatitis B surface antigen [HBsAg]) or positive test for hepatitis C antibody.
Monoclonal antibody therapy for cancer, radiotherapy, or chemotherapy within 3 weeks and targeted therapy within 2 weeks prior to the first dose of study treatment.
Prior administration of an ITK inhibitor.
Participants who need immediate cytoreductive therapy.
Participants requiring the concomitant use of strong inhibitors or inducers of CYP3A or who have received these within 5 half-lives or 14 days prior to the start of study treatment.
History of allogeneic hematopoietic stem cell transplantation.
Candidate for hematopoietic stem cell transplantation at screening.
History of progressive disease within 6 months of autologous hematopoietic stem cell transplantation.
Concurrent enrollment in another clinical study
Females who are pregnant, lactating, or intend to become pregnant during their participation in the study, starting with the screening visit through 6 months after the last dose of study treatment.
Participants who cannot ingest medications orally or who have malabsorption.

Where it is running

City of Hope National Medical Center — Duarte, California, United States (enrolling)
University of California, Irvine — Irvine, California, United States (enrolling)
University of California San Francisco — San Francisco, California, United States (enrolling)
Yale University — New Haven, Connecticut, United States (enrolling)
Sylvester Comprehensive Cancer Center University of Miami Miller School of Medicine — Miami, Florida, United States (enrolling)
Emory University — Atlanta, Georgia, United States (enrolling)
North Western University Robert H. Lurie Comprehensive Cancer Center RHLCCC — Chicago, Illinois, United States (enrolling)
University of Iowa — Iowa City, Iowa, United States (enrolling)
University of Maryland Medical Center — Baltimore, Maryland, United States (enrolling)
Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
Roger Cancer Center University of Michigan Health — Ann Arbor, Michigan, United States (enrolling)
Washington University in St. Louis — St Louis, Missouri, United States (enrolling)
Hackensack University Medical Center — Hackensack, New Jersey, United States (enrolling)
Icahn School of Medicine at Mount Sinai — New York, New York, United States (enrolling)
Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
Weill Cornell Medicine — New York, New York, United States (enrolling)
North Carolina Cancer Hospital — Chapel Hill, North Carolina, United States (enrolling)
The Ohio State University — Columbus, Ohio, United States (enrolling)
MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
University of Washington Fred Hutch Cancer Center — Seattle, Washington, United States (enrolling)
University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States (enrolling)
St Vincent's Hospital Sydney — Darlinghurst, New South Wales, Australia (enrolling)
St George Hospital — Kogarah, New South Wales, Australia (enrolling)
ICON Cancer Centre — South Brisbane, Queensland, Australia (enrolling)
Royal Adelaide Hospital — Adelaide, South Australia, Australia (enrolling)

Full record on ClinicalTrials.gov

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