Physical Exercise for Cognitive Rehabilitation of Patients With Bipolar Affective Disorder

Recruiting now · Not applicable

Conditions studied: Bipolar Disorder

In brief

The goal of this clinical trial is to evaluate the impact of Physical Exercise (PE), as an adjuvant treatment, on the cognition of patients diagnosed with Bipolar Disorder who present cognitive impairments, as well as its impact on quality of life and functionality and its association with physiological variables. Our specific goals are: 1. Evaluate the effect of PE on the neuropsychological functions of attention, memory, verbal fluency, executive function and processing speed in patients diagnosed with BD who present cognitive impairments in these domains. 2. To evaluate the effect of PE on the quality of life and functionality of patients diagnosed with BD, as well as possible associations with cognitive functions. 3. To evaluate possible correlations between physiological variables, such as cardiorespiratory indices, strength and body composition, and improvements in cognitive functions, quality of life and functionality.

Key facts

Study ID

NCT06560749

Run by

Beny Lafer

People needed

72

Starts

2024-08-20

Expected to finish

2027-09-01

Last updated by the study team

2026-07-16

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Bipolar disorder (BD) I and II according to DSM-5
• Age: 18 - 55 years old
• Complete primary education
• Euthymic (YMRS < 8 and MADRS < 12)
• Presence of cognitive impairments (COBRA > 14 and SCIP < 75)
• Estimated IQ ≥ 80
• No medication changes in the last month
• Having been without regular PE practice for six months
• Signature of the TCLE

You may not qualify if…

• Organic mental disorder
• BMI > 40
• Alcohol or drug abuse in the last 6 months
• Use of benzodiazepines or beta-blockers in the last month

Where it is running

• Gabriel Okawa Belizario — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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