Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID
Enrolling by invitation · Not applicable
Conditions studied: Long COVID
In brief
The purpose of this study is to evaluate the effects of fermented foods on bacterial gut microbiome diversity of long-COVID subjects.
Key facts
- Study ID
- NCT06560554
- Run by
- Mayo Clinic
- People needed
- 40
- Starts
- 2024-09-05
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-06-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult (> 18 years old)
- Patients who have long COVID symptoms
- a. Long COVID will be defined as: i. A previously documented COVID + infection within the last year ii. A presence of neurological symptoms that started within 4 weeks of the COVID infection (fatigue, difficulty concentrating, depression, anxiety) as per CDC definition of Long Covid.
- Own a smart device capable of downloading a food logging application. Able to understand and document informed consent
- Seen in the Mayo Clinic long-COVID Clinic within the Department of General Internal Medicine
You may not qualify if…
- History of dementia, moderate or severe cognitive dysfunction, developmental delay, psychotic disorders such as schizophrenia
- Unable to tolerate oral foods
- Potential contraindications to a fermented food diet (chronically immunosuppressed including organ transplant recipients)
- Neutropenic as listed in the "active problems" list in the EMR
- Undergoing chemotherapy at the time of consent
- Taking MAOIs at the time of consent.
- Active uncontrolled inflammatory bowel disease including ulcerative colitis, Crohn's disease, indeterminate colitis, irritable bowel syndrome (moderate or severe), infectious gastroenteritis, colitis or gastritis, Clostridium difficile infection (recurrent), malabsorptive diseases (such as Celiac disease), major surgery of the GI tract with the exception of cholecystectomy and/or appendectomy in the past 5 years, or any major bowel resection at any time.
- A reported consumption of 2 servings of probiotic fermented food per day in their normal baseline diet.
- Pregnancy
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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