IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia

Recruiting now · Phase 2/Phase 3

Conditions studied: Laparotomy

In brief

The purpose of this research study is to determine if the two common ways of administering additional opioids (morphine like substance, narcotic) with an epidural, either mixed in the epidural solution or given separately through the intravenous, are equally effective in controlling post-operative pain

Key facts

Study ID

NCT06559969

Run by

University of Iowa

People needed

80

Starts

2024-09-17

Expected to finish

2027-03-30

Last updated by the study team

2026-04-28

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age including and between 18 to 85 years old
• Planned open abdominal procedure with an incision that is or includes above the umbilicus, where epidural would normally be offered and epidural would be maintained for an average of 4 to 5 days
• Patient has consented for an epidural
• Patient is able to converse in English
• Patient is able to use a patient controlled pump

You may not qualify if…

• Has a known contraindication for an epidural
• Known mental or cognitive disability
• History of chronic opioid use or substance abuse disorder
• Pre-operative use of opioids
• History of chronic pain
• Routine use of marijuana
• Incarcerated
• Unable to converse in English
• Planned to remain intubated post-operatively
• Need for post-operative use of anticoagulant regiment that would be contraindicated with an indwelling epidural catheter
• End stage renal disease or dialysis
• Hepatic disease that affects metabolism of drugs
• Known contraindication to any of the study drugs
• Known pregnancy or positive pre-operative pregnancy test
• Known neurological condition that may affect motor or sensory systems

Where it is running

• University of Iowa Health Care — Iowa City, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.