Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy

Recruiting now

Conditions studied: Radiation Pneumonitis

In brief

Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.

Key facts

Study ID

NCT06557343

Run by

NHS Lothian

People needed

5

Starts

2024-10-25

Expected to finish

2026-12-01

Last updated by the study team

2026-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age over 18 years
• Patient has received thoracic radiotherapy and has clinical or radiological features in fitting with a diagnosis of Radiation Pneumonitis (onset one to four months post-RT with breathlessness, especially exertional, cough, chest discomfort, which is persistent over weeks, a chest x-ray [CXR] may demonstrate patchy or widespread opacification although can be normal.)
• Must be ambulant, oxygen independent with SpO2 >92% on air and haemodynamically stable to be considered safe for a bronchoscopy.
• Willing to undergo and likely able to tolerate bronchoscopy, ie. Can lie flat without compromising ventilation, and able to consent to the ELFMAN Protocol and SPITFIRE trial.

You may not qualify if…

• Contraindication to bronchoscopy, ie. Previously not tolerated, unable to lie flat, Sp02 <92% on air
• Patient requires admission or oxygen dependant
• Test positive for Covid-19 within the preceding six weeks to enrolment

Where it is running

• Edinburgh Cancer Centre — Edinburgh, United Kingdom (enrolling)
• Centre for Information Research, University of Edinburgh — Edinburgh, United Kingdom
• Henderson Lab — Edinburgh, United Kingdom

Full record on ClinicalTrials.gov

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