Promoting Resilience Among Adolescents and Young Adults With Sickle Cell Disease

Recruiting now · Not applicable

Conditions studied: Sickle Cell Disease

In brief

Adolescents and young adults with sickle cell disease (SCD) face challenges managing their illness and maintaining their well-being. This study proposes to test the feasibility and acceptability of a resilience-promoting intervention through a Collaborative Care Model. The primary goal is to determine with the resilience intervention (PRISM) is feasible and acceptable for adolescents and young adults with SCD. Exploratory outcomes include whether this intervention improves depression, anxiety, and pain interference.

Key facts

Study ID

NCT06555939

Run by

Boston Children's Hospital

People needed

25

Starts

2025-10-23

Expected to finish

2030-09-01

Last updated by the study team

2026-05-05

Who can join

Age: 8 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥ 8 and ≤ 25 years of age at baseline
• Diagnosed with Sickle Cell Disease (HbSS, HbSC, HbS-Beta Thalassemia, and other related hemoglobinopathies)
• Receiving Medical Care at the DFCI/BCH Blood Disorders Center.
• Scored > 9 on Patient Health Questionnaire 9-item (PHQ-9) or Generalized Anxiety Disorder (GAD)
• Able to speak English or Spanish language (for PRISM sessions)
• Able to read English or Spanish language (for completion of surveys)
• Cognitively able to participate in PRISM sessions and complete written questionnaires and surveys, as judged by the site investigator
• Willing and able to adhere to the study visit schedule and other protocol requirements

You may not qualify if…

• does not meet above criteria

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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