Ventilator Associated Pneumonia Multiplex PCR for Anti-Infective Regimens

Recruiting now · Not applicable

Conditions studied: Ventilator Associated Pneumonia

In brief

Ventilator-associated pneumonia (VAP) remains one of the main nosocomial infections acquired in the intensive care unit (ICU). VAP is pneumonia occurring 48 hours after intubation. Today, bronchoalveolar lavage (BAL) is used for microbiological diagnosis, with bacterial culture and antibiotic susceptibility results within 48 to 72 hours. Multiplex PCR can detect DNA of a number of bacteriae, as well as the presence of resistance genes. However, its clinical value in the ICU remains to be demonstrated. We think that the use of multiplex PCR with a panel adapted to the microbiology of VAP, could be an interesting method for clinicians in ICU.

Key facts

Study ID

NCT06554327

Run by

CHU de Reims

People needed

265

Starts

2025-03-06

Expected to finish

2026-10-06

Last updated by the study team

2025-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients, hospitalized in intensive care unit
• on mechanical ventilation for at least 48 hours
• Suspected VAP
• With an indication for bronchoalveolar lavage (BAL)

You may not qualify if…

• Patients under legal protection or without social security coverage
• Pregnant women
• Previous episode of VAP during the same hospitalization

Where it is running

• Damien JOLLY — Reims, France (enrolling)

Full record on ClinicalTrials.gov

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