Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry

Recruiting now · Not applicable

Conditions studied: Edentulous Alveolar Ridge, Peri-Implantitis, Peri-implant Mucositis, Prosthetic Infection, Prosthetic Complication

In brief

The goal of this clinical trial is to learn how different materials used in dental implants affect the surrounding gum tissue in adults who need dental implants. The main questions it aims to answer are: How do different materials (titanium, PEEK, zirconia, and lithium disilicate) affect inflammation around dental implants? What changes occur in inflammation markers in the gum tissue after 3 and 6 months? Researchers will compare the different materials to see which one causes the least amount of inflammation. Participants will: Receive dental implants made from different materials. Have samples of fluid from around their implants collected for analysis at 3 and 6 months. Undergo regular dental check-ups to measure gum health, such as bleeding and pocket depth around the implants.

Key facts

Study ID

NCT06554041

Run by

Harvard Medical School (HMS and HSDM)

People needed

40

Starts

2023-08-23

Expected to finish

2026-01-01

Last updated by the study team

2024-08-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must be 18 years or older.
• Participants must be edentulous with at least four missing teeth in the posterior region of the mandible or maxillae.
• Participants must have appropriate oral hygiene and periodontal status of natural teeth, with a pocket depth of 4mm or less and no bleeding.
• Dental implants must be fully integrated with no bone resorption or inflammation after three months of implant placement, confirmed by X-ray and clinical examination.
• Implant placement must be into natural bone without additional procedures such as sinus lift or bone augmentation.
• The procedure must be a standard implantation with no immediate implant placement.
• The height of the gingiva must be at least 3mm or more.

You may not qualify if…

• Patients with systemic diseases such as malignancy, diabetes, osteoporosis, or rheumatoid arthritis.
• Patients with a history of periodontal treatment.
• Patients who smoke or use tobacco.
• Patients who have received antibiotic treatment within three months prior to implantation.
• Pregnant individuals.

Where it is running

• VIC Clinic — Vilnius, Lithuania (enrolling)

Full record on ClinicalTrials.gov

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