Spastic Paraplegia - Centers of Excellence Research Network

Recruiting now

Conditions studied: Hereditary Spastic Paraplegia, Primary Lateral Sclerosis, SPG4, SPG5A, Spastic Paraplegia 4, Spastic Paraplegia 5A, Early Onset Hereditary Spastic Paraplegia, Neuromuscular Diseases, Spastic Paraplegia, Hereditary

In brief

The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).

Key facts

Study ID

NCT06553976

Run by

Boston Children's Hospital

People needed

100

Starts

2024-06-04

Expected to finish

2027-06-04

Last updated by the study team

2026-03-18

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female patients of all ages with a clinical and molecular diagnosis of hereditary spastic paraplegia type 4 (SPG4, SPAST) or hereditary spastic paraplegia type 5A (SPG5A, CYP7B1).

You may not qualify if…

• Not having such a diagnosis and/or not being related to such individual.

Where it is running

• Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
• University of Iowa Carver College of Medicine — Iowa City, Iowa, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• University of Michigan School of Medicine — Ann Arbor, Michigan, United States
• Columbia University - Irving Medical Center — New York, New York, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• Scottish Rite for Children — Dallas, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• University of Miami Miller School of Medicine — Miami, Florida, United States
• University of Washington School of Medicine — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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