Pre-operative Tumor Treating Fields in Patients With Resectable Lung Cancer
Starting soon · Not applicable
Conditions studied: NSCLC, Non Small Cell Lung Cancer
In brief
The purpose of this study is to study the clinical and biologic effects of Tumor Treatment Fields (TTFields) in patients undergoing resection of stage I-IIIA Non-Small Cell Lung Cancer (NSCLC). TTField is a non-invasive treatment that uses low-intensity electrical fields to treat cancer. Resection is the medical term for surgically removing part or all of a tissue, structure, or organ.
Key facts
- Study ID
- NCT06552000
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 18
- Starts
- 2026-07-01
- Expected to finish
- 2030-12-01
- Last updated by the study team
- 2026-02-23
Who can join
Age: 22 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of stage I-IIIA NSCLC planned for surgical resection.
- Eastern Cooperative Oncology Group (ECOG) 0-2 performance status.
- Willingness and ability to undergo planned correlative studies, including imaging tests.
- Fresh biopsy diagnostic material obtained from standard of care procedure to perform baseline correlatives (10-15 slides)-if not available, enrollment will be considered on a case-by-case basis after discussion with and approval by the Lead Site PI or Lead Site Co-Principal Investigator.
- Ability to understand and the willingness to sign a written informed consent.
- All men, as well as women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 30 days following completion of therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
- 6a. A female of child-bearing potential is any woman (regardless of sexual orientation, marital status, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
- • Has not undergone a hysterectomy or bilateral oophorectomy; or
- • Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
- Age ≥22 years at time of screening.
You may not qualify if…
- Receipt of prior therapy for the current NSCLC.
- Planned neoadjuvant therapy for the current NSCLC.
- History of major allergic reactions attributed to adhesive or compounds in TTFields micro-array.
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements.
- Pregnant or nursing patients due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.
- Use of electronic devices or prosthetics - i.e., pacemakers, defibrillators, spinal infusion pumps. Specific scenarios can be discussed with the Lead Site PI or Lead Site Co-Principal Investigator.
Where it is running
- The University of Texas Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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