National Network for Cardiovascular Genomics: Advancing Cardiovascular Healthcare for Hereditary Diseases in Brazil's Unified Health System Through a Multicenter Registry

Recruiting now

Conditions studied: Cardiomyopathy, Hypertrophic, Cardiomyopathy, Dilated, Cardiomyopathy Restrictive, Arrhythmogenic Right Ventricular Dysplasia, Non-Compaction Cardiomyopathy, Familial Hypercholesterolemia, Marfan Syndrome, Ehlers-Danlos Syndrome, Vascular Type, Loeys-Dietz Syndrome, Long QT Syndrome, Short Qt Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Sudden Cardiac Death

In brief

The goal of this observational study is to develop a registry of Brazilian patients with hereditary cardiovascular diseases, combining clinical and genomic data. The main questions it aims to answer are: Which genes are most commonly affected? What is the frequency of these genetic alterations in our population? Participants will be interviewed in routine medical care visits and their DNA will be sequenced.

Key facts

Study ID

NCT06546137

Run by

Hospital do Coracao

People needed

1211

Starts

2025-04-30

Expected to finish

2026-08-31

Last updated by the study team

2026-05-08

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of a hereditary cardiovascular disease according to current clinical guidelines
• Agree to receive genetic counseling
• Sign informed consent form
• Provide the information required in the case report form

You may not qualify if…

• Signature absent from informed consent form
• Inadequate buccal swab (sample may be collected twice)

Where it is running

• Centro de Pesquisa Silvestre Santé — Rio Branco, Acre, Brazil (enrolling)
• Centro de Pesquisas Clínicas Dr. Marco Mota — Maceió, Alagoas, Brazil (enrolling)
• Hospital Universitário da Unifap — Macapá, Amapá, Brazil (enrolling)
• Hospital de Messejana Dr. Carlos Alberto Studart Gomes — Fortaleza, Ceará, Brazil (enrolling)
• Hospital Evangélico de Vila Velha — Vila Velha, Espírito Santo, Brazil (enrolling)
• Hospital Universitário Professor Edgard Santos — Salvador, Estado de Bahia, Brazil (enrolling)
• Hospital Ana Nery - HAN/SESAB — Salvador, Estado de Bahia, Brazil (enrolling)
• Instituto de Cardiologia e Transplantes do Distrito Federal — Brasília, Federal District, Brazil (enrolling)
• Hospital das Clínicas da Universidade Federal de Goiás - HC-UFG — Goiânia, Goiás, Brazil (enrolling)
• Hospital Felicio Rocho - HFR — Belo Horizonte, Minas Gerais, Brazil (enrolling)
• Liga Mineira de Ressuscitação Cardiopulmonar — Belo Horizonte, Minas Gerais, Brazil (enrolling)
• Santa Casa de Misericórdia de Montes Claros — Montes Claros, Minas Gerais, Brazil (enrolling)
• Health & Care — Belém, Pará, Brazil (enrolling)
• Hospital Universitário Pedro Ernesto - UERJ — Rio de Janeiro, Rio de Janeiro, Brazil (enrolling)
• Instituto de Puericultura e Pediatria Martagão Gesteira — Rio de Janeiro, Rio de Janeiro, Brazil (enrolling)
• Hospital Universitário Clementino Fraga Filho - UFRJ — Rio de Janeiro, Rio de Janeiro, Brazil (enrolling)
• Instituto Nacional de Cardiologia — Rio de Janeiro, Rio de Janeiro, Brazil (enrolling)
• Hospital Universitário Onofre Lopes - UFRN — Natal, Rio Grande do Norte, Brazil (enrolling)
• Hospital das Clínicas de Porto Alegre - UFRGS — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)
• Instituto de Cardiologia - Fundação Universitária de Cardiologia de Porto Alegre - IC-FUC — Porto Alegre, Rio Grande do Sul, Brazil (enrolling)
• Instituto de Pesquisa e Ensino em Saúde - IPES — Porto Velho, Rondônia, Brazil (enrolling)
• Centro Multidisciplinar de Ensino Especializado e Pesquisa Ltda — Joinville, Santa Catarina, Brazil (enrolling)
• Hospital Universitário São Francisco na Providência de Deus, USF-SP — Bragança Paulista, São Paulo, Brazil (enrolling)
• Instituto PENSI — Consolação, São Paulo, Brazil (enrolling)
• Hospital Universitário da Universidade Federal de São Carlos — São Carlos, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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