Pharmacokinetics Vancomycin CVVHDF with OXiris Membrane

Recruiting now · Not applicable

Conditions studied: AKI - Acute Kidney Injury

In brief

This study is a general pharmacokinetic investigation of vancomycin in patients receiving continuous veno-venous hemodiafiltration (CRRT) with the oXiris membrane. This membrane offers the added benefit of absorbing inflammatory cytokines. In vitro studies show that vancomycin is reduced by around 20 percent in patients using the AN69ST membrane, which is part of the oXiris membrane's structure. However, there is currently a lack of in vivo studies demonstrating the impact of the oXiris membrane on vancomycin levels. Therefore, the hypothesis of this study is that vancomycin is also reduced by absorption in the oXiris membrane. This study measures the levels of vancomycin in these patients to determine the pharmacokinetic parameters.

Key facts

Study ID

NCT06543940

Run by

Mahidol University

People needed

8

Starts

2024-09-01

Expected to finish

2025-12-31

Last updated by the study team

2025-01-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged more than 18 years.
• Admitted to the intensive care unit of Ramathibodi Hospital.
• Under continuous renal replacement therapy (CRRT) with CVVHDF using oXiris filter.
• Received vancomycin at least once after starting CRRT with CVVHDF using oXiris filter.
• who have signed the informed consent document.

You may not qualify if…

• Patients with a history of vancomycin allergy.
• Patients expected to die within 24 hours after inclusion in study.
• Patients with circuit clotting occurring more than 2 hours during the blood draw period.
• Patients treated with extracorporeal membrane oxygenation (ECMO).
• Patients with a history of kidney transplantation.
• Pregnant or breastfeeding women.
• Patients who have decided to receive palliative care.
• Patients on hemodialysis or peritoneal dialysis.

Where it is running

• Facullty of Pharmacy Mahidol University — Bangkok, Payathi, Thailand (enrolling)

Full record on ClinicalTrials.gov

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