A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Age-related Macular Degeneration (AMD), Geographic Atrophy (GA)
In brief
This study is researching experimental (study) drugs called pozelimab and cemdisiran. The study is focused on participants who have Geographic Atrophy (GA) caused by Age-related Macular Degeneration (AMD). Geographic atrophy is a medical term that refers to later-stage cases of AMD which is an eye condition affecting central vision (what one sees straight ahead). The purpose of this study is to evaluate the progression rate of Geographic Atrophy in eyes of patients treated with cemdisiran alone or in combination with pozelimab compared to those treated with placebo. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug(s) * How much study drug(s) are in the blood at different times * Whether the body makes antibodies against the study drug(s) (which could make the study drug(s) less effective or could lead to side effects)
Key facts
- Study ID
- NCT06541704
- Run by
- Regeneron Pharmaceuticals
- People needed
- 975
- Starts
- 2024-10-30
- Expected to finish
- 2033-04-09
- Last updated by the study team
- 2026-07-29
Who can join
Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Optic Eye Care — Rowland Heights, California, United States (enrolling)
- UC Davis Health Eye Center — Sacramento, California, United States (enrolling)
- Barnet Dulaney Perkins Eye Center-Ophthamalogy — Chandler, Arizona, United States (enrolling)
- California Eye Specialists Medical Group, Inc. — Redlands, California, United States (enrolling)
- Associated Retina Consultants — Phoenix, Arizona, United States (enrolling)
- Retina Partners of Northwest Arkansas, PLLC — Springdale, Arkansas, United States (enrolling)
- Retinal Research Institute — Phoenix, Arizona, United States (enrolling)
- Retina Specialists of Beverly Hills- Department of Ophthalmology — Beverly Hills, California, United States (enrolling)
- Retina Macula Institute of Arizona — Scottsdale, Arizona, United States (enrolling)
- Barnet Dulaney Perkins Eye Center — Phoenix, Arizona, United States (enrolling)
- Retina Associates of Tuscan — Tucson, Arizona, United States (enrolling)
- Salehi Retina Institute dba Retina Associates of Southern California — Huntington Beach, California, United States (enrolling)
- University of California Irvine — Irvine, California, United States (enrolling)
- University of California San Diego, Jacobs Retina Center — La Jolla, California, United States (enrolling)
- South Coast Retina Center — Long Beach, California, United States (enrolling)
- Retina Vitreous Associates Medical Group — Beverly Hills, California, United States (enrolling)
- Kaiser Permanente Los Angeles Medical Center — Los Angeles, California, United States (enrolling)
- Jules Stein Eye Institute in David Geffen School of Medicine at UCLA — Los Angeles, California, United States (enrolling)
- Retinal Consultants Medical Group Inc Modesto — Modesto, California, United States (enrolling)
- Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California, United States (enrolling)
- California Retina Consultants — Oxnard, California, United States (enrolling)
- Eye Medical Center of Fresno — Fresno, California, United States (enrolling)
- California Eye Specialists Medical Group Inc. — Pasadena, California, United States (enrolling)
- Retina Consultants San Diego — Poway, California, United States (enrolling)
- Vrmg Inc — Sacramento, California, United States (enrolling)
Full record on ClinicalTrials.gov
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