RC48 in Combination With AK104 and Bevacizumab in OCCC

Recruiting now · Phase 2

Conditions studied: Ovary Cancer

In brief

Disitamab vedotin (RC48) in combination with AK104 (PD-1/CTLA-4 bispecific) and bevacizumab for the treatment of recurrent and persistent clear cell ovarian cancer: a single-arm, phase II, multicenter study (DAB OCC study)

Key facts

Study ID

NCT06540729

Run by

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

People needed

39

Starts

2024-09-24

Expected to finish

2030-08-01

Last updated by the study team

2025-07-08

Who can join

Age: 18 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• The pathological diagnosis confirms ovarian clear cell carcinoma. In cases of mixed carcinoma, a prerequisite is that clear cell carcinoma constitutes at least 70% of the tumor mass. Moreover, adherence to RECIST 1.1 criteria mandates the presence of at least one evaluable lesion.
• HER2 IHC ≥1+.
• Treatment-naïve individuals encompass those experiencing tumor progression during postoperative chemotherapy and those who, following platinum-containing neoadjuvant chemotherapy, have not undergone surgical intervention yet and subsequently manifested progression during or after platinum-containing chemotherapy, provided that they have received a maximum of 2 prior lines of chemotherapy.
• Recurrent patients, whether platinum-sensitive or platinum-resistant, include those lacking a platinum-free interval of ≥6 months and who, post-recurrence, have undergone re-administration of platinum-containing chemotherapy but have demonstrated an inability to tolerate toxic reactions, with a maximum of 2 lines of chemotherapy post-recurrence.
• Previous utilization of bevacizumab is permissible.
• Adequate bone marrow reserve function necessitates pre-operative blood routine parameters meeting specific criteria: white blood cell count ≥3.0×10\^9/L, neutrophil count ≥1.5×10\^9/L, platelet count ≥100×10\^9/L, and hemoglobin ≥80 g/L.
• atisfactory organ function entails biochemical test results within defined limits: AST ≤2.5× upper limit of normal (ULN), ALT ≤2.5× ULN, serum total bilirubin ≤1.5× ULN, and creatinine ≤1.5× ULN.
• ECOG performance status score ranging from 0 to 1.
• Patient participation is contingent upon voluntary execution of an informed consent form.

You may not qualify if…

• Patients with a history of immunotherapy, including treatments targeting PD-1, PD-L1, CAR-T, and CTLA-4.
• Patients diagnosed with other malignancies within the past five years, excluding skin cancer and thyroid cancer.
• Patients with an expected survival of ≤12 weeks.
• Patients with a known allergy to taxane-based medications.
• Patients who, based on clinical assessment, have contraindications for receiving immunotherapy and/or bevacizumab, such as uncontrolled infections, gastrointestinal fistula, autoimmune diseases, active hepatitis, or active bleeding.
• Patients currently undergoing treatment with investigational anti-cancer drugs in other clinical trials.
• Patients with any unstable condition or situation that may compromise their safety or adherence to the study protocol.

Where it is running

• Sun Yat-sen Memorial Hospital — Guanzhou, Guangdong, China (enrolling)

Full record on ClinicalTrials.gov

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