A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Multifocal Motor Neuropathy
In brief
The purpose of this Phase 2 study is to evaluate the safety, tolerability, pharmacometrics, and efficacy of Claseprubart (DNTH103) in participants with multifocal motor neuropathy (MMN).
Key facts
- Study ID
- NCT06537999
- Run by
- Dianthus Therapeutics
- People needed
- 36
- Starts
- 2024-09-17
- Expected to finish
- 2028-03-31
- Last updated by the study team
- 2026-06-23
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Must have given written informed consent before any study-related activities are carried out
- Adult males and females, 18 to 75 years of age (inclusive).
- Weight range between 40 to 120 kilograms (kg).
- Confirmed diagnosis of definite or probable MMN.
- Evidence of:
- Responsiveness to Ig treatment; and
- Receiving a stable Ig regimen
- Documented vaccinations against encapsulated bacteria in accordance with local requirements and vaccine availability.
- Female participants must be of nonchildbearing potential or if of childbearing potential, must agree not to donate ova, not to attempt to become pregnant and, if engaging in sexual intercourse with a male partner, must agree to use a highly effective method of contraception.
- Male participants must agree not to donate sperm and, if engaging in sexual intercourse with a female partner who could become pregnant, must agree to use an acceptable method of contraception or be surgically sterile for at least 90 days prior to Screening.
You may not qualify if…
- History or presence of significant medical/surgical condition including any acute illness or major surgery considered to be clinically significant or that could impact efficacy assessments.
- Any coexisting conditions which may interfere with outcome assessments (eg, severe diabetic neuropathy).
- Concurrent or previous use of rituximab, cyclophosphamide, mycophenolate mofetil, azathioprine, or cyclosporine. If a participant has previously used these medications, the last dose must be at least 6 months prior to randomization.
- Currently or previously on complement inhibitors including in a clinical trial setting.
- Prior history (at any time) of N. meningitidis infection.
- Diagnosis of an autoimmune disorder other than MMN.
- Positive test results for active human immunodeficiency virus (HIV-1 or HIV-2), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) antibodies during Screening.
- History of active malignancy within 5 years prior to Screening, except basal cell carcinoma of the skin, curatively resected squamous cell carcinoma of the skin, cervical carcinoma in situ curatively treated or low-grade prostate adenocarcinoma for which appropriate management is observation alone.
- Participation in another clinical study of an investigational drug within 90 days or 5 half-lives of the investigational agent (whichever is longer) prior to randomization (Day 1).
- Any other overlapping condition for which the condition or treatment of the condition may affect the study assessments or outcomes.
- Any other condition, including mental illness or prior therapy, that in the opinion of the Investigator would make the participant unsuitable for this study, including inability to cooperate fully with the requirements of the study protocol or likelihood of noncompliance with any study requirements.
Where it is running
- Clinical Study Site — Scottsdale, Arizona, United States (enrolling)
- Clinical Study Site — Los Angeles, California, United States (enrolling)
- Clinical Study Site — Bradenton, Florida, United States (enrolling)
- Clinical Study Site — Tampa, Florida, United States (enrolling)
- Clinical Study Site — Honolulu, Hawaii, United States (enrolling)
- Clinical Study Site — Kansas City, Kansas, United States (enrolling)
- Clinical Study Site — Cincinnati, Ohio, United States (enrolling)
- Clinical Study Site — Columbus, Ohio, United States (enrolling)
- Clinical Study Site — Houston, Texas, United States (enrolling)
- Cinical Study Site — Toronto, Canada (enrolling)
- Cinical Study Site — Beijing, China (enrolling)
- Clinical Study Site — Beijing, China (enrolling)
- Cinical Study Site — Shanghai, China (enrolling)
- Clinical Study Site — Aarhus, Denmark (enrolling)
- Clinical Study Site — Copenhagen, Denmark (enrolling)
- Clinical Study Site — Marseille, France (enrolling)
- Clinical Study Site — Paris, France (enrolling)
- Clinical Study Site — Rome, Italy (enrolling)
- Clinical Study Site — Kota Kinabalu, Malaysia (enrolling)
- Cinical Study Site — Kuala Lumpur, Malaysia (enrolling)
- Cinical Study Site — Kuala Lumpur, Malaysia (enrolling)
- Cinical Study Site — Permatang Pauh, Malaysia (enrolling)
- Cinical Study Site — Sarawak, Malaysia (enrolling)
- Clinical Study Site — Amsterdam, Netherlands (enrolling)
- Clinical Study Site — Utrecht, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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