EIT Assessment of Overdistension in ARDS Patients in Prone Position

Recruiting now

Conditions studied: Acute Respiratory Distress Syndrome

In brief

Mechanical ventilation in ARDS requires protective ventilation with low VT and PEEP. PEEP titration can improve lung recruitment in the dependent lung but with a risk of overdistension in the non-dependant lung. EIT can measure the distribution of tidal ventilation and assess overdistension and collapse during a PEEP titration in any position (prone or not). This study aims to measure the best PEEP as a compromise between recruitment and overdistension during a PEEP trial with EIT before and just after PP.

Key facts

Study ID

NCT06536543

Run by

University Hospital, Bordeaux

People needed

20

Starts

2024-10-15

Expected to finish

2026-05-01

Last updated by the study team

2026-01-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients hospitalized in the ICU and who suffered moderate or severe ARDS (Berlin criteria, PaO2/FiO2<150), intubated sedated, under myorelaxant and equipped with EIT
• Over the age of 18.

You may not qualify if…

• Broncho-pleural leaks
• Pregnant or breastfeeding woman.
• Guardianship or curatorship
• Deprived of liberty
• No health insurance
• Impossibility to correctly position the EIT belt (e.g., dressings, chest drainage, etc.)
• Contra indications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)

Where it is running

• CH Cote Basque — Bayonne, France (enrolling)
• Hopital Haut-Lévêque — Pessac, France (enrolling)

Full record on ClinicalTrials.gov

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