Mechanisms of Improving Fecal Continence Muscles Motor Function

Recruiting now · Not applicable

Conditions studied: Fecal Incontinence

In brief

The investigators hypothesize that different continence muscles have different fatigue characteristics and fatigue induced by resisted contractions will result in significant increase in contractility of the continence muscles and improvement of fecal incontinence severity.

Key facts

Study ID

NCT06532123

Run by

Medical College of Wisconsin

People needed

340

Starts

2025-07-15

Expected to finish

2030-03-01

Last updated by the study team

2025-10-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy volunteers without past or present history of fecal incontinence
• Patients age 18 years and older with reduced anal resting and or squeeze pressure, reflecting weakness of the anal sphincters who can perform the study

You may not qualify if…

• Any one less than 18 years old
• Neurological disorders like dementia, cerebrovascular diseases
• Muscle diseases like muscular dystrophy, myopathies
• Inflammatory bowel disease or celiac disease
• Neuro-muscular junction disorders/myasthenia gravis, Eaton-Lambert syndrome
• Organ prolapse, large rectocele(>2cm), rectal intussusception
• Hip dysplasia or recent hip surgery and immobile patients.
• Patients with complete normal anal resting and squeeze pressure
• Impaired rectal evacuation (dyssynergy defecation)
• Fecal incontinence completely due to loss of rectal sensation
• Subjects unable to contract their external anal sphincter at all

Where it is running

• Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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