Gut Microbiota in Chronic GI Diseases
Recruiting now
Conditions studied: Microbiota
In brief
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease. This will be complemented by a translational phase of human-mouse hybrid experiments in which germ-free mice will be colonized with feces from these patients with different GI disease and non-disease controls and we will compare symptoms, microbiota composition and histological changes in the gut and in the brain of the mice.
Key facts
- Study ID
- NCT06532110
- Run by
- McMaster University
- People needed
- 260
- Starts
- 2012-10-01
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2024-08-01
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Diagnosis of IBD, active celiac disease (aTTG positive + endoscopic view and histological findings compatible), IBS (Rome IV criteria or physician diagnosis) severe motility disorders (severe constipation, severe functional dyspepsia) gluten sensitivity (IBS diarrhea predominant with positive anti gliadin antibodies and negative aTTG), functional diarrhea (Rome IV criteria), anal fissure and/or fistula or non-disease control individual or 1st degree family member of celiac patient.
- Willingness to participate
- Signed Informed Consent
You may not qualify if…
- Antibiotics in the last month
- Probiotics in the previous month
Where it is running
- McMaster University — Hamilton, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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