Curcumin and EGCG Supplementation to Improve Serum BDNF and Mood Disturbance

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Mood Disturbance

In brief

The goal of this randomized placebo controlled trial is to examine mood disturbance and serum brain derived neurotrophic factor (BDNF) in people (age 18-50) with DASS-21 subscale scores \>9. The main questions it aims to answer are: Does curcumin and EGCG supplementation improve mood disturbance symptomology? Does curcumin and EGCG supplementation increase serum BDNF? Researchers will compare intervention versus placebo. Participants will consume an 8-week supplement of both: * 1,330mg/day curcumin * 350mg/day epigallocatechin gallate (EGCG)

Key facts

Study ID

NCT06531863

Run by

Auburn University

People needed

64

Starts

2024-09-30

Expected to finish

2025-08-01

Last updated by the study team

2025-02-14

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults age 18-50
• Depression subscale score of >9/21 on the DASS-21
• No change in medications or supplements over the past 3 months
• Can read and speak English

You may not qualify if…

• Currently consume curcumin or green tea daily
• Currently, pregnant, nursing, or trying to become pregnant
• Currently diagnosed with a perimenopausal disorder

Where it is running

• Auburn University School of Kinesiology — Auburn, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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