Microclots and Neutrophil Activation as Potential Indicators for Stroke Risk and Reperfusion Failure

Recruiting now

Conditions studied: Ischemic Stroke

In brief

Stroke remains a major health burden worldwide. Many patients are severely disabled and stay in need of care. Mechanical thrombectomy has dramatically improved outcomes for stroke patients with large vessel occlusions, yet 40-50% of patients with successful recanalization remain severely disabled despite successful recanalization, a scenario called "futile recanalization". One of the causes for this lack of treatment effect is capillary obstruction, or "no reflow", potentially resulting from activated neutrophils and micrometer-sized blood clots. To address this issue, we employ digital holotomographic and atomic force microscopy to investigate the structural and chemical characteristics of blood and clot material in stroke patients and individuals at high risk of developing a stroke. Our study elucidates the association of activated neutrophils and microclots with stroke risk, and may be associated with clinical outcome, stroke ethology and reperfusion failure in patients with stroke. Leveraging label-free microscopy tools, could potentially lead to the discovery of new biomarkers for individualized stroke treatment and prevention, ultimately offering rapid identification of at risk patients and improving clinical outcomes

Key facts

Study ID

NCT06530927

Run by

University of Zurich

People needed

500

Starts

2025-02-01

Expected to finish

2030-12-01

Last updated by the study team

2025-08-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients without acute stroke CS or CSG
• No previous stroke or previous stroke ≥ 1 year ago
• Signed informed consent
• Patients with acute stroke (AS-noTx, AS-IVT, AS-MT):
• Patients admitted with high suspicion of acute ischemic stroke
• Time of onset of stroke symptoms ≤ 12 hours
• Consent according to the regulations of research in an emergency situation
• Ischemic stroke later confirmed

You may not qualify if…

• All groups:
• Pregnancy
• Age under 18 years
• Acute Stroke no Therapy
• Acute treatment with IVT or with MT
• Acute Stroke IVT-Group • Acute treatment with MT or without IVT
• Acute Stroke MT-Group
• Acute treatment without MT

Where it is running

• University Hospital Zurich — Zurich, Canton of Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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