PI3K Inhibitors for the Treatment of Relapsed/Refractory Indolent T/NK-cell Lymphomas

Recruiting now · Phase 2

Conditions studied: Lymphoma, T-Cell, NK-LGL Leukemia, T-LGL Leukemia

In brief

Indolent T/NK-cell lymphomas are a heterogeneous group of lymphoproliferative diseases originating from T/NK cells, characterized by slow growth and proliferation, but currently remain incurable. For indolent T/NK-cell lymphomas that are unresponsive to first-line treatment, there are few treatment options available and the prognosis is poor. This study is an open-label, prospective clinical trial aimed at evaluating the feasibility, efficacy, and safety of PI3K inhibitors in the treatment of relapsed/refractory indolent T/NK-cell lymphomas. Patients will be treated with Linperlisib or Duvelisib, with an expected overall response rate of 60% for PI3K inhibitor treatment.

Key facts

Study ID: NCT06530550
Run by: Institute of Hematology & Blood Diseases Hospital, China
People needed: 51
Starts: 2024-08-10
Expected to finish: 2028-07-10
Last updated by the study team: 2025-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

the proportion of patients whose tumors have not progressed after treatment over a specific period of time. Specifically, DCR includes the percentage of patients who achieve complete response (CR), partial response (PR), and stable disease (SD).

You may not qualify if…

Here is the translated text:
Subjects who have previously used any PI3K inhibitors;
Clinical conditions of dysphagia, malabsorption, or other chronic gastrointestinal diseases that may interfere with compliance and/or absorption of the study drug;
Unable to discontinue medications that may prolong the QT interval (such as antiarrhythmic drugs) during the study period;
Active viral, bacterial, or fungal infections requiring treatment (e.g., pneumonia);
HBV or HCV infection (defined as HBsAg and/or HBcAb positive with HBV DNA copy number ≥ upper limit of normal reference value) or acute or chronic active hepatitis C (HCV) antibody positive;
History of immunodeficiency, including HIV positive, or other acquired or congenital immunodeficiency diseases, or history of organ transplantation, or history of allogeneic bone marrow or hematopoietic stem cell transplantation;
Received autologous hematopoietic stem cell transplantation within 90 days before the first dose of study treatment;
Presence of severe or uncontrolled cardiovascular disease;
Presence of severe concomitant diseases that endanger patient safety or are deemed by the investigator to affect the completion of the study (e.g., uncontrolled hypertension, diabetes, thyroid disease);
Pregnant or breastfeeding female patients, or baseline pregnancy test positive for women of childbearing potential;
Diagnosed or treated for other malignancies within the past 5 years;
Any other condition that the investigator deems unsuitable for participation in the study.

Where it is running

Institute of Hematology & Blood Diseases Hospital — Tianjin, Tianjin Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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