Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and Integrative Modeling
Recruiting now
Conditions studied: Dementia, Alzheimer Disease, Dementia With Lewy Bodies, Vascular Dementia, Frontotemporal Dementia, Mild Cognitive Impairment, Corticobasal Syndrome, Progressive Supranuclear Palsy, Parkinson Disease, Primary Progressive Aphasia
In brief
To develop a model to predict disease progression in a large cohort of patients across a variety of neurodegenerative diseases, including Mild Cognitive Impairment (MCI) and dementia due to any neurodegenerative disease, including Alzheimer's Disease (AD), Lewy Body Disease (LBD), Vascular Disease (VaD) and Frontotemporal lobar degeneration (FTLD).
Key facts
- Study ID
- NCT06529744
- Run by
- University Health Network, Toronto
- People needed
- 500
- Starts
- 2023-11-11
- Expected to finish
- 2027-11-01
- Last updated by the study team
- 2025-11-20
Who can join
Age: 30 and older, up to 95. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Possible or probable diagnosis of MCI or early dementia
- Age 30-95
- Study partner who has some weekly contact with patient. Some of the neuropsychological assessment require collateral from close contacts to assess cognition and functioning. Since neurodegenerative diseases can be associated with reduced cognition, including reduced awareness of one's own impairments, participants will be assessed for their capacity to consent at all study visits.
- Must, in the opinion of the site investigator, be able to complete most study procedures.
You may not qualify if…
- Participants who are not able to complete the majority of assessments in the opinion of the PI are excluded from the study. Exclusion criteria are evaluated at the site investigator's discretion; if the site investigator believes that the participant's symptoms are due to causes other than neurodegeneration, despite the presence of an exclusionary condition, the investigator may overrule the exclusion.
Where it is running
- Toronto Western Hospital, University Health Network — Toronto, Ontario, Canada (enrolling)
- Baycrest — North York, Ontario, Canada
- Sunnybrook Health Sciences Centre — Toronto, Ontario, Canada
- Centre for Addiction and Mental Health — Toronto, Ontario, Canada
Full record on ClinicalTrials.gov
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