Proteinopathies Expression in Skin of Neurodegenerative Disorders
Recruiting now
Conditions studied: Alzheimer Disease, Frontotemporal Dementia, Parkinson Disease, Atypical Parkinsonism, Amyotrophic Lateral Sclerosis, Normal Pressure Hydrocephalus
In brief
The goal of this observational study is to compare the aggregation pattern of proteinopathies (alpha-synuclein, amyloid-beta, phosphorylated tau and transactive response DNA -binding protein 43 \[TDP43\]) in skin biopsies of patients with a neurodegenerative disease like Alzheimer's disease, frontotemporal lobe dementia, Parkinson's disease, atypical Parkinsonism, amyotrophic lateral sclerosis or normal pressure hydrocephalus. The main question it aims to answer is: * Is there a specific pattern of aggregation of proteinopathies in skin biopsies in each neurodegenerative disease in comparison to healthy control subjects? Skin biopsies will be analyzed using immunohistochemistry and immunofluorescence for detection of alpha-synuclein, amyloid-beta, phosphorylated tau and TAR DNA binding protein 43, and the aggregation patterns will be compared between patients with a neurodegenerative disease vs patient with normal pressure hydrocephalus vs healthy control subjects.
Key facts
- Study ID
- NCT06528964
- Run by
- Universidad Autonoma de San Luis Potosí
- People needed
- 40
- Starts
- 2023-12-20
- Expected to finish
- 2026-11-01
- Last updated by the study team
- 2024-12-16
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Patients or controls that have a personal history of cerebrovascular disease, psychiatric disease, post traumatic dementia or HIV related dementia
- Patients in which the diagnosis is not clear or hasn't been confirmed
- Patients or controls that have a neuroinfection
- Patients or controls that a diagnosed skin disease
- Patients that have an "atypical" presentation of the disease
- Patients or controls that have diagnosis of a coagulopathy
Where it is running
- Hospital Central Dr. Ignacio Morones Prieto — San Luis Potosí City, Mexico (enrolling)
Full record on ClinicalTrials.gov
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